Results 121 to 130 of about 73,225 (285)

Properties of Microsomal and Soluble Diacylglycerol Kinase in Rat Liver [PDF]

, 1978
Hideo Kanoh, Björn Åkesson
openalex   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Pharmacological Evidence for Involvement of Phospholipase D, Protein Kinase C, and Sodium-Calcium Exchanger in -Adrenoceptor-Mediated Negative Inotropy in Adult Mouse Ventricle

Journal of Pharmacological Sciences, 2003
The intracellular signalling pathway for a-adrenoceptor-mediated negative inotropy was studied pharmacologically in isolated adult mouse ventricle. The negative inotropy was inhibited by GF-109203X, a nonselective protein kinase C inhibitor.
Kazuhide Nishimaru, Yoshio Tanaka, Hikaru Tanaka, Koki Shigenobu   +3 more
doaj   +1 more source

Differential Effects of Liver Regeneration on Aging‐Related Changes in Gene Expression and Metabolic Function

Aging Cell, EarlyView.
The age‐specific gene expression status of aged mouse hepatocytes is mostly resolved and rejuvenated when liver regeneration is completed; whereas the age‐specific intracellular metabolic status detected in the liver of aged mice is largely maintained and not rejuvenated even after liver regeneration is completed.
Ryo Murayama, Kenichi Horisawa, Shizuka Miura, Sumiaki Taniguchi, Jinghao Shu, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Kousei Ishigami, Atsushi Suzuki   +9 more
wiley   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice

Scientific Reports, 2017
Diabetic nephropathy (DN) is one of vascular complications of diabetes and is caused by abnormal protein kinase C activation as a result of increased diacylglycerol (DG) production in diabetic hyperglycaemia.
Daiki Hayashi, Keiko Yagi, Chihong Song, Shuji Ueda, Minoru Yamanoue, Matthew Topham, Toshinobu Suzaki, Naoaki Saito, Noriaki Emoto, Yasuhito Shirai   +9 more
doaj   +1 more source

The role of the neuromodulator adenosine in alcohols actions. [PDF]

, 1997
The interaction between the neuromodulator adenosine and adenosine receptors on the surface of neurons modifies the neurons responses to neurotransmitters.
Diamond, Ivan, Dohrman, D, Gordon, A
core  

Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer

British Journal of Pharmacology, EarlyView.
Background and Purpose Chemotherapeutic treatment for colorectal cancer (colorectal cancer) allows for increased patient overall survival. However, current therapeutic regimens are often associated with the development of adverse drug reactions, which represent a morbidity, mortality and economic issue.
Ana Rita Simoes, Silvia Carlés González, María del Carmen Lopez‐Doldan, Goretti Duran, Ana Fernández‐Montes, Maria Perfecta Fernandez, Mercedes Salgado Fernandez, Jesus Garcia Mata, David Paez, Pau Riera, Elisabeth Guino, Luis Lopez‐Fernandez, Belen Garcia de Santiago, Elena López Aspiroz, Augusto Rojas, Antoni Castells, Sergi Castellvi‐Bel, Clara Ruiz Ponte, Veronika Vymetalkova, Angel Carracedo, Ceres Fernandez‐Rozadilla   +20 more
wiley   +1 more source

Liganded peroxisome proliferator-activated receptors (PPARs) preserve nuclear histone deacetylase 5 levels in endothelin-treated Sprague-Dawley rat cardiac myocytes.

PLoS ONE, 2014
Ligand activation of peroxisome proliferator-activated receptors (PPARs) prevents cardiac myocyte hypertrophy, and we previously reported that diacylglycerol kinase zeta (DGKζ) is critically involved.
Haining Zhang, Zongjun Shao, Caroline P Alibin, Crystal Acosta, Hope D Anderson   +4 more
doaj   +1 more source

Calcium and cAMP are second messengers in the adipokinetic hormone-induced lipolysis of triacylglycerols in Manduca sexta fat body

Journal of Lipid Research, 1999
We have previously shown that stereospecific hydrolysis of stored triacylglycerol by a phosphorylatable triacylglycerol-lipase is the pathway for the adipokinetic hormone-stimulated synthesis of sn-1, 2-diacylglycerol in insect fat body.
Estela L. Arrese, Matthew T. Flowers, Justin L. Gazard, Michael A. Wells   +3 more
doaj   +1 more source