Results 141 to 150 of about 45,123 (293)

SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling

, 2011
Diacylglycerol kinases (DGKs) metabolize diacylglycerol to phosphatidic acid. In T lymphocytes, DGKα acts as a negative regulator of TCR signaling by decreasing diacylglycerol levels and inducing anergy.
Bettio, V, Chianale, F., Baldari, Cosima T., Zhong, X. P., van Blitterswijk, Wim J., Patrussi L, Parolini, Ornella, Zhong, Xiao-Ping, Kim E. Nichols, Bettio V, Baldanzi, G., Nichols KE, Baldari, Cosima, Traini S, Andrea Pighini, Patrussi, Laura, Wim J. van Blitterswijk, Mesturini R, Schweighoffer, Tamas, Zhong XP, Bettio, Valentina, Ornella Parolini, Pighini, Andrea, Graziani, Andrea, Song, S., Fabiola Sinigaglia, Porporato PE, Mesturini, R., Sinigaglia, F., Nicoletta Filigheddu, Andrea Graziani, Bettio, V., Nichols, K. E., Parolini, O., Sara Traini, Chianale, Federica, Paolo E. Porporato, Xiao-Ping Zhong, Ignacio Rubio, Nichols, Kim E., Rubio, Ignacio, van Blitterswijk WJ, Filigheddu, Nicoletta, Zhong, Xiao Ping, Schweighoffer T, Rubio I, Gianluca Baldanzi, Traini, S., Schweighoffer, T., Pighini A, Baldari CT, Porporato, Paolo E., Porporato, Paolo, Rainero, Elena, Rainero, E., Elena Rainero, van Blitterswijk W. J., Traini, Sara, Song SP, Graziani A., Laura Patrussi, Tamas Schweighoffer, Baldanzi, Gianluca, Rubio, I., Filigheddu, N., Graziani, A., Pighini, A., Rainero, E, Chianale F, Porporato, P. E., Parolini O, Valentina Bettio, Rainero E, Song, Shuping, Mesturini, Riccardo, Riccardo Mesturini, Shuping Song, Cosima T. Baldari, Sinigaglia, Fabiola, Federica Chianale   +79 more
core   +1 more source

Systems‐Level Plant Responses Reveal Pseudomonas‐Mediated Growth Promotion in Brachypodium Under Nitrogen Limitation

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant growth–promoting bacteria can enhance plant performance under nutrient limitation, yet the underlying plant molecular responses remain incompletely resolved. We investigated growth promotion by Pseudomonas koreensis in Brachypodium distachyon under contrasting nitrogen (N) regimes using time‐resolved phenotyping, elemental analysis ...
Stefan Sanow, Melissa Mantz, Holger Wissel, Atul Bhatnagar, Elena Sturm, Jana M. Kelm, Robert Walker, Andreas Lücke, Gabriel Schaaf, Pitter F. Huesgen, Ute Roessner, Michelle Watt, Borjana Arsova   +12 more
wiley   +1 more source

Diacylglycerol kinases: A look into the future of immunotherapy

Advances in Biological Regulation
Cancer still represents the second leading cause of death right after cardiovascular diseases. According to the World Health Organization (WHO), cancer provoked around 10 million deaths in 2020, with lung and colon tumors accounting for the deadliest forms of cancer.
Miguel Martin-Salgado, Ane Ochoa-Echeverría, Isabel Mérida   +2 more
openaire   +3 more sources

ACTH increases diacylglycerol content and subcellular redistribution of protein kinase C in the rat adrenal in vivo

, 1987
Treatment of rats in vivo with ACTH provoked increases in whole adrenal contents of phosphatidylinositol and diacylglycerol. Concomitantly, C-kinase activity decreased in cytosol and increased stoichiometrically in the membrane fraction.
Farese, Robert V., Fanjul, Luisa F., Davis, John S., Cooper, Denise R., de Ruiz Galarreta, C. M.   +4 more
core   +1 more source

Alkyl analogs of diacylglycerol as activators of protein kinase C

, 1987
Diacylglycerols which activate protein kinase C have the 1,2-sn configuration. Short-chain saturated fatty acids or long-chain unsaturated fatty acids are required for supporting the potency of these lipids.
Françoise Heymans, Noël Marrec, Corinne Da Silva, Jean-Jacques Godfroid, Heymans, Françoise, Da Silva, Corinne, Godfroid, Jean-Jacques, Marrec, Noël, Monique Castagna, Castagna, Monique   +9 more
core   +1 more source

The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy. [PDF]

Molecules, 2022
Hayashi D, Shirai Y.
europepmc   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Diacylglycerol kinase activity in rat liver nuclei

, 1994
Membrane-depleted rat liver nuclei contain diacylglycerol (DAG) kinase showing a specific activity which doubles that of the whole homogenate. In contrast, cytoplasmic and palsma membrane marker enyzmes attain a specific activity of 0.4% at the most ...
BERTAGNOLO, Valeria, BORGATTI P, CAPITANI S., PREVIATI, Maurizio, MAZZONI M, OSTI F   +5 more
core   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Src-mediated activation of alpha-diacylglycerol kinase is required for hepatocyte growth factor-induced cell motility RID G-6323-2011

, 2000
Diacylglycerol kinases are involved in cell signaling either as regulators of diacylglycerol levels or as intracellular signal-generating enzymes. However neither their role in signal transduction nor their biochemical regulation has been elucidated ...
van Blitterswijk WJ, Maffe A, BALDANZI, GIANLUCA, Cutrupi S, Comoglio PM, Graziani A., Giraudo E, Bussolino F, Gramaglia D, Schaap D   +9 more
core   +1 more source