Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management
MedComm, Volume 7, Issue 10, October 2026.Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi +9 more
wiley +1 more source
Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates
Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.An alkyne‐tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the Kennedy pathway, allowing CuAAC‐based visualization of PE and affinity capture of PE‐conjugated LC3, ubiquitin, and GPI‐anchored proteins.
Yuan‐Ting Cho +5 more
wiley +2 more sources
Diacylglycerol Kinase Puts the Brakes on Airway Smooth Muscle Contraction. [PDF]
Am J Respir Cell Mol Biol, 2021 Lukovic E, Emala C.
europepmc +1 more source
MedComm, Volume 7, Issue 10, October 2026.BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley +1 more source
Myristic acid selectively augments β-tubulin levels in C2C12 myotubes via diacylglycerol kinase δ. [PDF]
FEBS Open Bio, 2022 Sakai H +3 more
europepmc +1 more source
FASEB BioAdvances, Volume 8, Issue 10, October 2026.In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Zenab Shahzad +5 more
wiley +1 more source
Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma. [PDF]
Int J Mol Sci, 2022 Hernandez-Lara MA +7 more
europepmc +1 more source
Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm
British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley +1 more source
The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation
International Endodontic Journal, Volume 59, Issue 10, Page 2028-2045, October 2026.ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli +3 more
wiley +1 more source
Ca2+ -induced structural changes and intramolecular interactions in N-terminal region of diacylglycerol kinase alpha. [PDF]
Protein Sci, 2022 Takahashi D +7 more
europepmc +1 more source