Results 171 to 180 of about 76,688 (279)

Role of diacylglycerol kinase in autophagy, ER biogenesis, and triterpene metabolism. [PDF]

Autophagy Rep, 2022
Reju KS, S CP, Manjithaya R, Dk VR.
europepmc   +1 more source

Cooperation of Gq, Gi, and G12/13 in Protein Kinase D Activation and Phosphorylation Induced by Lysophosphatidic Acid [PDF]

, 2003
To examine the contribution of different G-protein pathways to lysophosphatidic acid (LPA)-induced protein kinase D (PKD) activation, we tested the effect of LPA on PKD activity in murine embryonic cell lines deficient in Galpha q/11 (Galpha q/11 KO ...
Gu, Jennifer, Rozengurt, Enrique, Slice, Lee W., Yuan, Jingzhen   +3 more
core  

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Lycium barbarum polysaccharides enhance testicular spermatogenesis in d‐galactose‐induced aging rats via calcium signaling

Andrology, Volume 14, Issue 2, Page 496-515, February 2026.
Abstract Background Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d‐galactose‐induced testicular dysfunction in reproductively senescent rats are not fully understood.
Wenxin Ma, Chang Liu, Jing Pu, Ziyu Liu, Na Hu, Li Yang, Dongmei Chen, Hongmei Li, HuiMing Ma   +8 more
wiley   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, Volume 293, Issue 3, Page 781-805, February 2026.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Immunomodulatory Mechanism of Baiyaojian Decoction on Periodontitis: Network Pharmacology, Single‐Cell RNA Sequencing and Molecular Docking

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Periodontitis is one of the most common oral inflammatory diseases. Baiyaojian decoction, known for its prominent immunomodulatory and anti‐inflammatory properties, shows significant potential in treating periodontitis, though its molecular mechanisms remain unknown. The active ingredients and therapeutic targets were determined by integrating
Bing‐jun Chen, Ming‐ming Li, Zhao‐yu Zheng, Wen‐qin Jin, Zhao Jin, Yu‐ling Zuo   +5 more
wiley   +1 more source

A single‐MYB transcription factor GmMYB331 regulates seed oil accumulation and seed size/weight in soybean

Journal of Integrative Plant Biology, Volume 68, Issue 2, Page 470-485, February 2026.
The soybean transcription factor GmMYB331 regulates oil content and seed size. Moderate expression of GmMYB331 significantly enhanced seed oil accumulation, and strong expression promoted increased seed size. This research provides a genetic resource and theoretical foundation for high‐yield and quality breeding in soybean.
Zhou‐Ya Wang, Lu‐Yao Zhang, Bin Zhou, Jing‐Jing Liang, Yan‐Bao Tian, Zhi‐Hao Jiang, Jian‐Jun Tao, Cui‐Cui Yin, Shou‐Yi Chen, Wan‐Ke Zhang, Jin‐Song Zhang, Wei Wei   +11 more
wiley   +1 more source

Impact of time‐restricted feeding on metabolic health and adipose tissue metabolism in aged female mice with high‐fat diet‐induced obesity

The Journal of Physiology, Volume 604, Issue 3, Page 1137-1157, 1 February 2026.
Abstract figure legend A 10 week time‐restricted feeding (TRF) regimen was implemented in aged female mice following 12 weeks of high‐fat diet (HFD) feeding. TRF partially reversed HFD‐induced weight and fat mass gain, reduced adipocyte size and increased size heterogeneity in white adipose tissue.
Theresa Bushman, Hongming Su, Xiaoli Chen   +2 more
wiley   +1 more source

Phospholipid Interconversion and Transport Are Altered in Glaucoma

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Decreased phosphatidylserine (PS) and increased phosphatidylethanolamine (PE) occur in both trabecular meshwork (TM) cells and aqueous humor due to aberrant phosphatidylserine decarboxylase (PSD) over‐expression, and variation in levels of individual PS or PE species differing by only a few acyl chains occurs due to impaired lipid transport due to ...
Genea Edwards, Ruminder Kaur, Anna Mueller, Noël Ziebarth, Richard K. Lee, Sanjoy K. Bhattacharya   +5 more
wiley   +1 more source

Vitamin E functions by association with a novel binding site on the 67 kDa laminin receptor activating diacylglycerol kinase. [PDF]

J Nutr Biochem, 2022
Hayashi D, Mouchlis VD, Okamoto S, Namba T, Wang L, Li S, Ueda S, Yamanoue M, Tachibana H, Arai H, Ashida H, Dennis EA, Shirai Y.   +12 more
europepmc   +1 more source