Results 171 to 180 of about 916,035 (361)

Diacylglycerol kinases: A look into the future of immunotherapy

Advances in Biological Regulation
Cancer still represents the second leading cause of death right after cardiovascular diseases. According to the World Health Organization (WHO), cancer provoked around 10 million deaths in 2020, with lung and colon tumors accounting for the deadliest forms of cancer.
Miguel Martin-Salgado, Ane Ochoa-Echeverría, Isabel Mérida   +2 more
openaire   +3 more sources

Empowering AlphaFold2 for protein conformation selective drug discovery with AlphaFold2-RAVE [PDF]

Small molecule drug design hinges on obtaining co-crystallized ligand-protein structures. Despite AlphaFold2's strides in protein native structure prediction, its focus on apo structures overlooks ligands and associated holo structures. Moreover, designing selective drugs often benefits from the targeting of diverse metastable conformations. Therefore,
arxiv   +1 more source

Plant‐derived vesicle‐like nanoparticles in food crops: emerging insights into nutritional biofortification and biomedical applications

Plant Biotechnology Journal, EarlyView.
Summary Food crops, as the cornerstone of human nutrition, not only provide essential macronutrients but also encompass a rich spectrum of bioactive compounds that promote health. Of particular significance are underutilized minor crops, which contain unique beneficial components with proven nutraceutical properties. These valuable bioactive components
Jie Wang, Zhaosheng Kong
wiley   +1 more source

Molecular changes in agroinfiltrated leaves of Nicotiana benthamiana expressing suppressor of silencing P19 and coronavirus‐like particles

Plant Biotechnology Journal, EarlyView.
Summary The production of coronavirus disease 2019 vaccines can be achieved by transient expression of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 in agroinfiltrated leaves of Nicotiana benthamiana. Relying on bacterial vector Agrobacterium tumefaciens, this process is favoured by co‐expression of viral silencing suppressor
Louis‐Philippe Hamel, Francis Poirier‐Gravel, Marie‐Ève Paré, Rachel Tardif, Marc‐André Comeau, Pierre‐Olivier Lavoie, Andréane Langlois, Marie‐Claire Goulet, Dominique Michaud, Marc‐André D'Aoust   +9 more
wiley   +1 more source

Unravelling Candidate Genes Associated With Blast Disease Resistance in an Elite Green Super Rice Varietal Panel Using Genome‐Wide Association Study

Plant Pathology, Volume 74, Issue 4, Page 968-984, May 2025.
A genome‐wide association study of 134 rice parental lines from the IRRI‐GSR programme using virulent isolates M101‐1‐2‐9‐1 and M‐64‐1‐3‐9‐1 revealed novel resistance sources and associations near Pib (Chr2) and Pi‐ta/Ptr (Chr12).. ABSTRACT Rice blast disease, caused by the filamentous fungus Magnaporthe oryzae, significantly threatens global rice ...
Harshita Saxena, Varunseelan Murugaiyan, Bikash Ghimire, Christian John Robiso, Erik Jon De Asis, Mary Jeanie Yanoria, Paul L. Raymer, Bochra Amina Bahri, Jauhar Ali   +8 more
wiley   +1 more source

Prediction of Small Molecule Kinase Inhibitors for Chemotherapy Using Deep Learning [PDF]

arXiv, 2019
The current state of cancer therapeutics has been moving away from one-size-fits-all cytotoxic chemotherapy, and towards a more individualized and specific approach involving the targeting of each tumor's genetic vulnerabilities. Different tumors, even of the same type, may be more reliant on certain cellular pathways more than others.
arxiv  

Diacylglycerol Kinase Alpha

Definitions, 2020

semanticscholar   +1 more source

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

, 2002
The possibility that lipid-induced insulin resistance in human muscle is related to alterations in diacylglycerol (DAG)/protein kinase C (PKC) signaling was investigated in normal volunteers during euglycemic-hyperinsulinemic clamping in which plasma ...
Samar I. Itani, N. Ruderman, Frank A. Schmieder, G. Boden   +3 more
semanticscholar   +1 more source

The relationship between cytosolic Ca2+, sn-1,2-diacylglycerol and inositol 1,4,5-trisphosphate elevation in platelet-activating-factor-stimulated rabbit platelets. Influence of protein kinase C on production of signal molecules [PDF]

, 1991
Christine Murphy, M Elmore, Stuart Kellie, John Westwick   +3 more
openalex   +1 more source

Diacylglycerol Kinase ζ Attenuates Doxorubicin‐Induced Cardiotoxicity Through p53 Degradation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Doxorubicin‐induced cardiotoxicity is still an important medical problem associated with a high mortality rate in cancer survivors. p53 plays a key role in doxorubicin‐induced cardiotoxicity.
Shingo Tachibana, Yoichiro Otaki, Tetsu Watanabe, Jun Goto, Haruki Ochi, Toshiaki Tanaka, Hiroe Ono, Ryuhei Yamaguchi, Junya Sato, Hiroki Takahashi, Takanori Arimoto, Kaoru Goto, Masafumi Watanabe   +12 more
doaj   +1 more source