Results 201 to 210 of about 916,035 (361)

Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]

open access: yes, 2008
To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L.   +7 more
core   +1 more source

Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes

open access: yesFEBS Open Bio, Volume 15, Issue 6, Page 940-948, June 2025.
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya   +3 more
wiley   +1 more source

Signaling at the membrane interface by the DGK/SK enzyme family

open access: yesJournal of Lipid Research, 2009
The sphingosine (SK) and diacylglycerol (DGK) kinases have become the subject of considerable focus recently due to their involvement as signaling enzymes in a variety of important biological processes.
Daniel M. Raben, Binks W. Wattenberg
doaj  

Alternative splicing of the human diacylglycerol kinase ζ gene in muscle [PDF]

open access: green, 1997
Li Ding   +5 more
openalex   +1 more source

Halymenia durvillei Extracts Exert Antiobesity Effects by Targeting hosl‐1‐Mediated Lipolysis in a Glucose‐Induced Caenorhabditis elegans Model

open access: yeseFood, Volume 6, Issue 3, June 2025.
This study demonstrates the antiobesity potential of Halymenia durvillei (H. durvillei) extracts using a Caenorhabditis elegans (C. elegans) obesity model. The extracts significantly reduced total fat accumulation, lowered reactive oxygen species (ROS) levels, and extended the lifespan in glucose‐fed C. elegans. These beneficial effects may be mediated
Kawita Chumphoochai   +8 more
wiley   +1 more source

Haptoglobin and Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background Anticancer chemotherapy is an underappreciated contributor to cancer cachexia, an often‐irreversible body‐wasting condition that causes 20%–30% of cancer‐related deaths. An obstacle to predicting, monitoring and understanding the mechanisms underlying chemotherapy cachexia is that each cancer (and subtype) is assigned different ...
Dean G. Campelj   +9 more
wiley   +1 more source

Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha

open access: yesNeuro-Oncology, 2018
Inan Olmez   +21 more
semanticscholar   +1 more source

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