Results 211 to 220 of about 539,017 (238)
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Diacylglycerol kinase control of protein kinase C
Biochemical Journal, 2019Abstract The diacylglycerol kinases (DGK) are lipid kinases that transform diacylglycerol (DAG) into phosphatidic acid (PA) in a reaction that terminates DAG-based signals. DGK provide negative regulation to conventional and novel protein kinase C (PKC) enzymes, limiting local DAG availability in a tissue- and subcellular-restricted ...
Isabel Mérida +3 more
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1996
Abstract Diacylglycerol kinase (DGK) reverses the normal flow of phospholipid biosynthesis by phosphory/ating diacylglycerol back to phosphatidic acid. DGK consists of a number of isozymes with different enzymological properties. The three isozymes so far sequenced, however, share highly conserved regions including two sets each of EF-
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Abstract Diacylglycerol kinase (DGK) reverses the normal flow of phospholipid biosynthesis by phosphory/ating diacylglycerol back to phosphatidic acid. DGK consists of a number of isozymes with different enzymological properties. The three isozymes so far sequenced, however, share highly conserved regions including two sets each of EF-
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Diacylglycerol kinases: at the hub of cell signalling
Biochemical Journal, 2007DGKs (diacylglycerol kinases) are members of a unique and conserved family of intracellular lipid kinases that phosphorylate DAG (diacylglycerol), catalysing its conversion into PA (phosphatidic acid). This reaction leads to attenuation of DAG levels in the cell membrane, regulating a host of intracellular signalling proteins that have evolved the ...
Isabel, Mérida +2 more
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Nuclear diacylglycerol kinases: regulation and roles
Frontiers in Bioscience, 2008The diacylglycerol-kinases are a family of related lipid kinases. There are currently 10 known isoforms of diacylglycerol kinases that are categorized into five groups based on similarities in their primary sequence. All of these enzymes catalyze the transfer of the gamma-phosphate of ATP to one lipid second messenger, diacylglycerol, thereby ...
Daniel M, Raben, Becky, Tu-Sekine
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Diacylglycerol Kinases: Regulation and Signaling Roles
Thrombosis and Haemostasis, 2002SummaryDiacylglycerol kinases (DGKs) are thought to attenuate diacylglycerol signals by converting diacylglycerol to phosphatidic acid. The nine mammalian diacylglycerol kinases that have been identified are widely expressed, but each isoform has a unique tissue and subcellular distribution.
Matthew K, Topham, Stephen M, Prescott
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Inhibition of diacylglycerol kinases as a physiological way to promote diacylglycerol signaling
Advances in Biological Regulation, 2014Diacylglycerol is a key regulator of cell physiology, controlling the membrane recruitment and activation of signaling molecules. Accordingly, diacylglycerol generation and metabolism are strictly controlled, allowing for localized regulation of its concentration.
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Regulation of diacylglycerol kinase by phosphorylation
Advances in Biological Regulation, 2012Y, Shirai, M, Ikeda, N, Saito
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Regulation and Functions of Diacylglycerol Kinases
Chemical Reviews, 2011Yulia V, Shulga +2 more
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Regulation of ‘signalling diacylglycerol’ in cells: the importance of diacylglycerol kinase
Biochemical Society Transactions, 1996M N, Hodgkin +3 more
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