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Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol [PDF]
FEBS Letters, 2015 Diacylglycerol kinase (DGK) η plays important roles in various patho-physiological events such as oncogenesis. In this study, we performed an enzymological characterization of DGKη splice variant 1 (DGKη1).
Hiromichi Sakai, Fumio Sakane
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International Journal of Biochemistry and Cell Biology, 1997
Fumio Sakane, Hideo Kanoh
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Fumio Sakane, Hideo Kanoh
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Phosphorylation of pig brain diacylglycerol kinase by endogenous protein kinase [PDF]
FEBS Letters, 1986 Pig brain diacylglycerol kinase did not catalyze autophosphorylation. However, the kinase was phosphorylated on serine, when immunoprecipitated from the partially purified enzyme preparation preincubated with Mg2+ and [γ-32P]ATP.
Hideo Kanoh
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Diacylglycerol directly stimulates the insulin receptor tyrosine kinase [PDF]
FEBS Letters, 1996 Studies with detergent: lipid mixed micelles reveal that diacylglycerol directly stimulates the intrinsic tyrosine kinase activity of the insulin receptor. Kinetic analyses indicate that diacylglycerol activates the kinase by causing a marked increase in
Alexandra C. Newton
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Cellular Signalling, 2004
Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to form phosphatidic acid. In most cases, members of this large family of enzymes appear to bind and regulate proteins activated by either diacylglycerol or phosphatidic acid. Proteins that appear to be regulated, in part, by DGKs include protein kinase Cs, RasGRPs, and phosphatidylinositol ...
Bai, Luo +3 more
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Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to form phosphatidic acid. In most cases, members of this large family of enzymes appear to bind and regulate proteins activated by either diacylglycerol or phosphatidic acid. Proteins that appear to be regulated, in part, by DGKs include protein kinase Cs, RasGRPs, and phosphatidylinositol ...
Bai, Luo +3 more
openaire +2 more sources
Diacylglycerol kinases in cancer
Advances in Biological Regulation, 2017Diacylglycerol kinases (DGK) are a family of enzymes that catalyze the transformation of diacylglycerol into phosphatidic acid. In T lymphocytes, DGKα and ζ limit the activation of the PLCγ/Ras/ERK axis, providing a critical checkpoint to inhibit T cell responses. Upregulation of these isoforms limits Ras activation, leading to hypo-responsive, anergic
Isabel Mérida +7 more
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Properties and functions of diacylglycerol kinases
Cellular Signalling, 2000Diacylglycerol kinases (DGKs) phosphorylate the second-messenger diacylglycerol (DAG) to phosphatidic acid (PA). The family of DGKs is well conserved among most species. Nine mammalian isotypes have been identified, and are classified into five subgroups based on their primary structure.
W J, van Blitterswijk, B, Houssa
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An endogenous regulator of diacylglycerol kinase
Biochemical and Biophysical Research Communications, 1988During the initial steps of the subcellular fractionation of rat brain homogenate, we recovered more than 100% of diacylglycerol kinase activity. The unusually high yields prompted us to examine the possibility that we had removed an endogenous inhibitor from diacylglycerol kinase during those steps.
I M, Jeng, N, Klemm, C Z, Wu
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Diacylglycerol kinases in signal transduction
Chemistry and Physics of Lipids, 1999Diacylglycerol kinase (DGK) phosphorylates the second messenger diacylglycerol (DAG) to phosphatidic acid. A family of nine mammalian isotypes have been identified. Their primary structure shows a diverse array of conserved domains, such as a catalytic domain, zinc fingers, pleckstrin homology domains and EF-hand structures, known to interact with ...
W J, van Blitterswijk, B, Houssa
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Diacylglycerol, phosphatidic acid, and the converting enzyme, diacylglycerol kinase, in the nucleus
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2006There exists phosphoinositide (PI) cycle in the nucleus, which is operated differentially from the classical PI cycle at the plasma membrane. Evidence has been accumulated that nuclear PIs and the related enzymes are closely involved in a variety of nuclear processes, although the details remain to be elucidated. In this mini review, some components of
Kaoru, Goto +2 more
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