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Cellular Signalling, 2004
Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to form phosphatidic acid. In most cases, members of this large family of enzymes appear to bind and regulate proteins activated by either diacylglycerol or phosphatidic acid. Proteins that appear to be regulated, in part, by DGKs include protein kinase Cs, RasGRPs, and phosphatidylinositol ...
Bai, Luo +3 more
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Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to form phosphatidic acid. In most cases, members of this large family of enzymes appear to bind and regulate proteins activated by either diacylglycerol or phosphatidic acid. Proteins that appear to be regulated, in part, by DGKs include protein kinase Cs, RasGRPs, and phosphatidylinositol ...
Bai, Luo +3 more
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Diacylglycerol kinases in cancer
Advances in Biological Regulation, 2017Diacylglycerol kinases (DGK) are a family of enzymes that catalyze the transformation of diacylglycerol into phosphatidic acid. In T lymphocytes, DGKα and ζ limit the activation of the PLCγ/Ras/ERK axis, providing a critical checkpoint to inhibit T cell responses. Upregulation of these isoforms limits Ras activation, leading to hypo-responsive, anergic
Isabel Mérida +7 more
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The International Journal of Biochemistry & Cell Biology, 1997
Recent observations suggest that diacylglycerol kinase (DGK) is one of the key enzymes involved in the regulation of signal transduction. It attenuates protein kinase C activity and cell cycle progression of T-lymphocytes, through controlling the intracellular levels of the second messengers, diacylglycerol and phosphatidic acid.
Hideo Kanoh, Fumio Sakane
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Recent observations suggest that diacylglycerol kinase (DGK) is one of the key enzymes involved in the regulation of signal transduction. It attenuates protein kinase C activity and cell cycle progression of T-lymphocytes, through controlling the intracellular levels of the second messengers, diacylglycerol and phosphatidic acid.
Hideo Kanoh, Fumio Sakane
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2003
Publisher Summary Diacylglycerol (DAG) is a prolific second messenger that activates proteins involved in a variety of signaling cascades. Because it can associate with a diverse set of proteins, DAG potentially activates numerous signaling cascades. Thus, its accumulation needs to be strictly regulated.
Steve M. Prescott, Matthew K. Topham
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Publisher Summary Diacylglycerol (DAG) is a prolific second messenger that activates proteins involved in a variety of signaling cascades. Because it can associate with a diverse set of proteins, DAG potentially activates numerous signaling cascades. Thus, its accumulation needs to be strictly regulated.
Steve M. Prescott, Matthew K. Topham
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An endogenous regulator of diacylglycerol kinase
Biochemical and Biophysical Research Communications, 1988During the initial steps of the subcellular fractionation of rat brain homogenate, we recovered more than 100% of diacylglycerol kinase activity. The unusually high yields prompted us to examine the possibility that we had removed an endogenous inhibitor from diacylglycerol kinase during those steps.
Wu Cuizhen, Nancy Klemm, Ingming Jeng
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Diacylglycerol kinases: at the hub of cell signalling [PDF]
Biochemical Journal, 2007 DGKs (diacylglycerol kinases) are members of a unique and conserved family of intracellular lipid kinases that phosphorylate DAG (diacylglycerol), catalysing its conversion into PA (phosphatidic acid). This reaction leads to attenuation of DAG levels in the cell membrane, regulating a host of intracellular signalling proteins that have evolved the ...
Antonia Ávila-Flores +2 more
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Properties and functions of diacylglycerol kinases
Cellular Signalling, 2000Diacylglycerol kinases (DGKs) phosphorylate the second-messenger diacylglycerol (DAG) to phosphatidic acid (PA). The family of DGKs is well conserved among most species. Nine mammalian isotypes have been identified, and are classified into five subgroups based on their primary structure.
Brahim Houssa, Wim J. van Blitterswijk
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2009
Diacylglycerol kinase (DGK, EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). DGK belongs to a well-conserved family of proteins found in diverse species, such as Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, mammals, plants, and bacteria (Merida et al.
Arisz, S.A., Munnik, T.
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Diacylglycerol kinase (DGK, EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). DGK belongs to a well-conserved family of proteins found in diverse species, such as Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, mammals, plants, and bacteria (Merida et al.
Arisz, S.A., Munnik, T.
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