Results 71 to 80 of about 518,832 (292)

Diagnostic Biomarkers to Diagnose Acute Allograft Rejection After Liver Transplantation: Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies

Frontiers in Immunology, 2019
Objective: A systematic review and meta-analysis of diagnostic biomarkers for noninvasive diagnosis of acute allograft rejection following liver transplantation.Background: Noninvasive blood and urine markers have been widely explored in recent decades ...
Felix Krenzien, Felix Krenzien, Eriselda Keshi, Katrin Splith, Silvan Griesel, Kaan Kamali, Igor M. Sauer, Linda Feldbrügge, Linda Feldbrügge, Johann Pratschke, Annekatrin Leder, Moritz Schmelzle   +11 more
doaj   +1 more source

A Flexible Method for Diagnostic Accuracy with Biomarker Measurement Error

Mathematics, 2023
Diagnostic biomarkers are often measured with errors due to imperfect lab conditions or analytic variability of the assay. The ability of a diagnostic biomarker to discriminate between cases and controls is often measured by the area under the receiver ...
Ching-Yun Wang, Ziding Feng
doaj   +1 more source

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program [PDF]

, 2017
Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's ...
Albin, Roger, Alcalay, Roy N., Babcock, Debra, Bowman, F. DuBois, Chen-Plotkin, Alice, David, Karen K., Dawson, Ted M., Dewey, Richard B., Jr., Foroud, Tatiana, German, Dwight, Gwinn, Katrina, Huang, Xuemei, Lungu, Codrin, Petyuk, Vlad, Potashkin, Judith A., Rosenthal, Liana S., Saunders-Pullman, Rachel, Scherzer, Clemens R., Sieber, Beth-Anne, St Hillaire-Clarke, Coryse, Sutherland, Margaret, Swanson-Fischer, Christine, Vaillancourt, David E., Walt, David R., West, Andrew B., Zhang, Jing   +25 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

TM4SF4 is a diagnostic biomarker accelerating progression of papillary thyroid cancer via AKT pathway

Cancer Biology & Therapy
The incidence of papillary thyroid cancer (PTC) has been steadily rising, though the underlying mechanism remains unclear. This study aims to elucidate the biological role of TM4SF4 in the PTC progression.
Lizhi Lin, Jialiang Wen, Tiansheng Xu, Yuhao Si   +3 more
doaj   +1 more source

Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer

Molecular Oncology, 2018
Cervical cancer is one of the leading causes of cancer death in women globally, despite the widespread use of cytology/human papillomavirus (HPV) screening. In the present study, we aimed to identify the potential role of microRNA (miRNA) as a diagnostic
Stephanie S. Liu, Karen K. L. Chan, Daniel K. H. Chu, Tina N. Wei, Lesley S. K. Lau, Siew F. Ngu, Mandy M. Y. Chu, Ka Yu Tse, Philip P. C. Ip, Enders K. O. Ng, Annie N. Y. Cheung, Hextan Y. S. Ngan   +11 more
doaj   +1 more source

Potential biomarkers for retinopathy of prematurity identified by circular RNA profiling in peripheral blood mononuclear cells

Frontiers in Immunology, 2022
PurposeThis study aims to reveal the altered expression profiles of circular RNAs (circRNAs) in the peripheral blood mononuclear cells (PBMCs) of patients with retinopathy of prematurity (ROP), and to identify potential biomarkers for ROP diagnosis ...
Yun Li, Yun Li, Haixiang Zhou, Haixiang Zhou, Qian Huang, Qian Huang, Wei Tan, Wei Tan, Yuting Cai, Yuting Cai, Zicong Wang, Zicong Wang, Jingling Zou, Jingling Zou, Bingyan Li, Bingyan Li, Shigeo Yoshida, Yedi Zhou, Yedi Zhou   +18 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Transcript PHF19-207 May Be a Long Non-Coding RNA with Tumor-Promoting Role in Colon Cancer

Biomolecules
Recent pan-cancer transcriptome analysis has revealed differential activity of two alternative PHF19 gene promoters in malignant versus non-malignant gut mucosa.
Dunja Pavlovic, Tamara Babic, Sofija Ignjatovic, Katarina Pavlovic, Sandra Dragicevic, Aleksandra Nikolic   +5 more
doaj   +1 more source

Long noncoding RNA MyD88 functions as a promising diagnostic biomarker in hepatocellular carcinoma

Frontiers in Endocrinology, 2023
BackgroundHepatocellular carcinoma (HCC) is one of the most frequent malignancies. Alpha-fetoprotein (AFP) has some limitations in diagnosing early HCC.
Zhihuai Wang, Zhihuai Wang, Peng Gao, Weijun Sun, Adeel ur Rehman, Jiakai Jiang, Suobao Xu, Cailin Xue, Chunfu Zhu, Chunfu Zhu, Xihu Qin, Xihu Qin   +11 more
doaj   +1 more source