Results 61 to 70 of about 373,653 (317)

Biomarker assessment in ROC curve analysis using the length of the curve as an index of diagnostic accuracy: the binormal model framework [PDF]

, 2020
In receiver operating characteristic (ROC) curve analysis, the area under the curve (AUC) is undoubtedly the most widely used index of diagnostic accuracy for the assessment of the utility of a biomarker or for the comparison of competing biomarkers ...
Franco-Pereira, Alba M., Nakas, Christos T., Pardo, M. Carmen   +2 more
core   +1 more source

HOXA9-methylated DNA as a diagnostic biomarker of ovarian malignancy [PDF]

, 2021
Aim: In ovarian cancer, methylated HOXA9 (meth-HOXA9) has been proposed as a relevant biomarker, however, its role in the carcinogenic development remains unknown.
Faaborg, Louise, Waldstrøm, Marianne, Andersen, Rikke F.; id_orcid, Petersen, Christina B., Jakobsen, Anders, Steffensen, Karina D.   +5 more
core   +1 more source

Urine metabolomics phenotyping and urinary biomarker exploratory in mild cognitive impairment and Alzheimer’s disease

Frontiers in Aging Neuroscience, 2023
IntroductionAlzheimer’s disease is a prevalent disease with a heavy global burden and is suggested to be a metabolic disease in the brain in recent years.
Yuye Wang, Yuye Wang, Yu Sun, Yu Wang, Shuhong Jia, Yanan Qiao, Zhi Zhou, Wen Shao, Xiangfei Zhang, Jing Guo, Xincheng Song, Xincheng Song, Xiaoqian Niu, Dantao Peng, Dantao Peng, Dantao Peng   +15 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Target product profile for a diagnostic assay to differentiate between bacterial and non-bacterial infections and reduce antimicrobial overuse in resource-limited settings: an expert consensus [PDF]

, 2016
Acute fever is one of the most common presenting symptoms globally. In order to reduce the empiric use of antimicrobial drugs and improve outcomes, it is essential to improve diagnostic capabilities.
Zorzet, A., Tadesse, BT, Paul N Newton, Newton, P.N., Quique Bassat (89288), Lubell, Yoel,, Zorzet, Anna, D'Acremont, Valerie,, Bassat, Quique,, Norbert Heinrich, Crump, John A.,, Paul N. Newton (132889), Yoel Lubell, Zorzet, A, Valerie D’Acremont (3079494), Dolinger, D.L., Anna Zorzet, Anna Zorzet (3079506), Newton, PN, Iveth J. González (137011), Chua, Arlene,, Rodwell, T.J., D'Acremont, V., González, Iveth J, David L Dolinger, Heinrich, Norbert,, Dittrich, Sabine, Dittrich, S, Gonzalez, Iveth J.,, Rodwell, Timothy J.,, González, I.J., Norbert Heinrich (175590), Tängdén, Thomas,, Page, A.L., Chua, A., Dolinger, David L., Dolinger, David L, John A. Crump (231237), Tilahun, Birkneh Tilahun, Thomas Tängdén, Newton, Paul, Birkneh Tilahun Tadesse, Lubell, Y, Francis Moussy, Timothy J Rodwell, Bassat, Quique, Newton, Paul N.,, Tängdén, T., Tadesse, Birkneh Tilahun,, Thomas Tängdén (3079503), Arlene Chua, Moussy, F, Moussy, F., Rodwell, Timothy J., Page, Anne-Laure, Lubell, Yoel, Tadesse, B.T., Bassat Orellana, Quique, Valerie D'Acremont, Birkneh Tilahun Tadesse (769116), Crump, John A., Bassat, Q, John A Crump, Chua, A, Newton, Paul N., Bassat, Q., Acremont, Valerie D’, González, Iveth J., Sabine Dittrich (85996), Tängdén, Thomas, Newton, Paul N, David L. Dolinger (3079500), Page, Anne-Laure, Moussy, Francis, Anne-Laure Page, Crump, J.A., Rodwell, Timothy J, Crump, JA, Tadesse, Birkneh Tilahun, Timothy J. Rodwell (3079497), Iveth J González, González, IJ, Chua, Arlene, Zorzet, Anna,, Heinrich, N, Dittrich, S., Yoel Lubell (88683), Page, Anne-Laure,, Page, AL, D'Acremont, Valerie, Dolinger, David L.,, Heinrich, N., Tängdén, T, Crump, John A, Heinrich, Norbert, Dittrich, Sabine,, Arlene Chua (134856), Sabine Dittrich, Dolinger, DL, Anne-Laure Page (247439), D'Acremont, V, Rodwell, TJ, Moussy, Francis,, Quique Bassat, Lubell, Y., Francis Moussy (127840)   +105 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Development and evaluation of statistical approaches in proteomic biomarker discovery [PDF]

, 2011
A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacological responses to a therapeutic intervention.
Patel, Amit
core  

Circulating Fibroblast Growth Factor 21 (Fgf21) as Diagnostic and Prognostic Biomarker in Renal Cancer [PDF]

, 2016
Background: The finding of new biomarkers is needed to have a better sub-classification of primary renal tumors (RCC) as well as more reliable predictors of outcome and therapy response.
Knott, María Elena, Minatta, J.N, Roulet, L., De Lorenzo, M, Gueglio G., Ranuncolo, Stella Maris, Nuñez, M, Pasik, Leonardo, Puricelli, Lydia Ines   +8 more
core   +1 more source

DTI Histogram and Texture Features as Early Predictors of Post-Radiotherapy Cognitive Decline

Applied Sciences
Background: Radiotherapy for brain tumors can induce cognitive decline, yet most studies examine white matter (WM) damage six months post-treatment, overlooking early microstructural changes.
Jincheng Wang, Philip Kyeremeh Jnr Oppong, Maho Kitagawa, Hidefumi Aoyama, Shunsuke Onodera, Satoshi Terae, Khin Khin Tha   +6 more
doaj   +1 more source

Decision Criteria for Large Vessel Occlusion Using Transcranial Doppler Waveform Morphology

Frontiers in Neurology, 2018
Background: The current lack of effective tools for prehospital identification of Large Vessel Occlusion (LVO) represents a significant barrier to efficient triage of stroke patients and detriment to treatment efficacy.
Samuel G. Thorpe, Corey M. Thibeault, Nicolas Canac, Seth J. Wilk, Thomas Devlin, Robert B. Hamilton   +5 more
doaj   +1 more source