Results 51 to 60 of about 373,653 (317)

Biomarkers and diagnostics in heart failure

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013
Heart failure (HF) biomarkers have dramatically impacted the way HF patients are evaluated and managed. B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are the gold standard biomarkers in determining the diagnosis and prognosis of HF, and studies on natriuretic peptide-guided HF management look promising.
Gaggin, Hanna K., Januzzi, James L.
openaire   +2 more sources

Blood Biomarkers: Democratizing Alzheimer’s Diagnostics

Neuron, 2020
Currently available biomarkers for Alzheimer's disease are of limited availability due to high costs and perceived invasiveness. New studies reveal that Alzheimer's pathologies now can be reliably quantified in vivo using regular blood tests.
Zetterberg, H, Blennow, K
openaire   +3 more sources

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Human epididymis protein 4 (HE4) in benign and malignant diseases [PDF]

, 2012
Background: Human epididymis protein 4 (HE4) is described as a useful new biomarker in ovarian cancer. As HE4 is neither tumor nor organ specific, we intensively investigated the occurrence of this protein in female and male patients with various benign ...
Kirschenhofer, Angela, Lenhard, Miriam, Fürst, Sophie, Krocker, Katja, Mayr, Doris, Hofmann, Karin, Burges, Alexander, Hertlein, Linda, Stieber, Petra, Nagel, Dorothea   +9 more
core   +1 more source

Intra-tumoral spatial heterogeneity in breast cancer quantified using high-dimensional protein multiplexing and single cell phenotyping

Breast Cancer Research
Background Breast cancer is a highly heterogeneous disease where variations of biomarker expression may exist between individual foci of a cancer (intra-tumoral heterogeneity).
Alison M. Cheung, Dan Wang, Mary Anne Quintayo, Yulia Yerofeyeva, Melanie Spears, John M. S. Bartlett, Lincoln Stein, Jane Bayani, Martin J. Yaffe   +8 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Pooling serum samples may lead to loss of potential biomarkers in SELDI-ToF MS proteomic profiling.

, 2008
BACKGROUND: High throughput proteomic technology offers promise for the detection of disease biomarkers and proteomic signature patterns but biomarker discovery studies can be limited by cost factors when large sample size numbers are required.
Dan Agranoff, S Tariq Sadiq, Agranoff Dan, Sadiq S Tariq, Agranoff, D, Sadiq, ST   +5 more
core   +1 more source

Identification of the Mycobacterium ulcerans protein MUL_3720 as a promising target for the development of a diagnostic test for Buruli ulcer [PDF]

, 2015
Buruli ulcer (BU) caused by Mycobacterium ulcerans is a devastating skin disease, occurring mainly in remote West African communities with poor access to health care.
Miriam Bolz, Charles Moes, Gerd Pluschke, Marie Thérèse Ruf (691166), Stinear, Timothy Paul, Jean Pierre Dangy, Katharina Röltgen, Andrea Vettiger, Nicholas Jay Tobias, Anita Dreyer (691164), Dreyer, Anita, Scherr, Nicole, Moes, Charles, Nicole Scherr, Jean Pierre Dangy (691165), Andrea Vettiger (436255), Tobias, Nicholas Jay, Charles Moes (691168), Bolz, Miriam, Miriam Bolz (309717), Vettiger, Andrea, Röltgen, Katharina, Gerd Pluschke (7855), Ruf, Marie Thérèse, Timothy Paul Stinear, Katharina Röltgen (120045), Nicholas Jay Tobias (691167), Marie Thérèse Ruf, Anita Dreyer, Timothy Paul Stinear (691169), Dangy, Jean Pierre, Pluschke, Gerd, Nicole Scherr (396149)   +32 more
core   +1 more source

Heterogeneity and immune microenvironment of early invasive estrogen receptor-positive breast cancer reveal an immune-rich subset

npj Breast Cancer
Approximately 80% of all breast cancer cases are estrogen receptor-positive (ER+). This subtype is known to have distant recurrences in a subset of patients after adjuvant endocrine therapy, partially due to the heterogeneity of the disease.
Drashti Jain, Linda Liao, Vida Talebian, Megan Hopkins, Mary Anne Quintayo, Cheryl Crozier, Jane Bayani, Alison M. Cheung, Martin Yaffe, John Bartlett, Melanie Spears   +10 more
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source