Results 51 to 60 of about 533,448 (310)

Salivary Biomarkers for Oral Squamous Cell Carcinoma Diagnosis and Follow-Up: Current Status and Perspectives [PDF]

, 2019
Oral cancer is the sixth most common cancer type in the world, and 90% of it is represented by oral squamous cell carcinoma (OSCC). Despite progress in preventive and therapeutic strategies, delay in OSCC diagnosis remains one of the major causes of high
Campisi, Giuseppina, Cristaldi, Marta, Di Fede, Olga, Giuliana, Giovanna, Mauceri, Rodolfo, Panzarella, Vera   +5 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Intra-tumoral spatial heterogeneity in breast cancer quantified using high-dimensional protein multiplexing and single cell phenotyping

Breast Cancer Research
Background Breast cancer is a highly heterogeneous disease where variations of biomarker expression may exist between individual foci of a cancer (intra-tumoral heterogeneity).
Alison M. Cheung, Dan Wang, Mary Anne Quintayo, Yulia Yerofeyeva, Melanie Spears, John M. S. Bartlett, Lincoln Stein, Jane Bayani, Martin J. Yaffe   +8 more
doaj   +1 more source

From aptamer-based biomarker discovery to diagnostic and clinical applications: an aptamer-based, streamlined multiplex proteomic assay [PDF]

, 2010
Recently, we reported an aptamer-based, highly multiplexed assay for the purpose of biomarker identification. To enable seamless transition from highly multiplexed biomarker discovery assays to a format suitable and convenient for diagnostic and life ...
Christopher Bock, Dom Zichi, Evaldas Katilius, Glenn M. Sanders, Jonathon D. Vaught, Larry Gold, Nancy Kim, Nicholas A. Saccomano, Sheri K. Wilcox, Stephan Kraemer, Tracy R. Keeney   +10 more
core   +1 more source

Blood Biomarkers: Democratizing Alzheimer’s Diagnostics

Neuron, 2020
Currently available biomarkers for Alzheimer's disease are of limited availability due to high costs and perceived invasiveness. New studies reveal that Alzheimer's pathologies now can be reliably quantified in vivo using regular blood tests.
Zetterberg, H, Blennow, K
openaire   +3 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Heterogeneity and immune microenvironment of early invasive estrogen receptor-positive breast cancer reveal an immune-rich subset

npj Breast Cancer
Approximately 80% of all breast cancer cases are estrogen receptor-positive (ER+). This subtype is known to have distant recurrences in a subset of patients after adjuvant endocrine therapy, partially due to the heterogeneity of the disease.
Drashti Jain, Linda Liao, Vida Talebian, Megan Hopkins, Mary Anne Quintayo, Cheryl Crozier, Jane Bayani, Alison M. Cheung, Martin Yaffe, John Bartlett, Melanie Spears   +10 more
doaj   +1 more source

Cancer biomarker development from basic science to clinical practice [PDF]

, 2018
The amount of published literature on biomarkers has exponentially increased over the last two decades. Cancer biomarkers are molecules that are either part of tumour cells or secreted by tumour cells.
Ali, Asif, Ali, Zafar, Oien, Karin A., Yousafzai, Yasar Mehmood   +3 more
core  

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Urine metabolomics phenotyping and urinary biomarker exploratory in mild cognitive impairment and Alzheimer’s disease

Frontiers in Aging Neuroscience, 2023
IntroductionAlzheimer’s disease is a prevalent disease with a heavy global burden and is suggested to be a metabolic disease in the brain in recent years.
Yuye Wang, Yuye Wang, Yu Sun, Yu Wang, Shuhong Jia, Yanan Qiao, Zhi Zhou, Wen Shao, Xiangfei Zhang, Jing Guo, Xincheng Song, Xincheng Song, Xiaoqian Niu, Dantao Peng, Dantao Peng, Dantao Peng   +15 more
doaj   +1 more source