Results 91 to 100 of about 1,490,029 (341)

Three Dimensional Electrical Impedance Tomography [PDF]

, 1996
The electrical resistivity of mammalian tissues varies widely and is correlated with physiological function. Electrical impedance tomography (EIT) can be used to probe such variations in vivo, and offers a non-invasive means of imaging the internal ...
A Albert, AM Dijkstra, B. H. Brown, BH Brown, BH Brown, CJ Kotre, D. C. Barber, DA Witsoe, DB Geselowitz, DC Barber, DC Barber, DC Barber, DC Barber, DC Barber, DS Holder, ET McAdams, FA Duck, GH Golub, J Goble, JP Morucci, KS Rabbani, LA Geddes, P. Metherall, PC Hansen, R Pethig, R. H. Smallwood, RD Stoy, SG Dawids   +27 more
core   +1 more source

Diagnostic Imaging in COPD [PDF]

Seminars in Respiratory and Critical Care Medicine, 2010
Chronic obstructive pulmonary disease (COPD) is a pathological pulmonary condition characterized by expiratory airflow obstruction due to emphysematous destruction of the lung parenchyma and small airways remodeling. Although spirometry is a very useful diagnostic tool for screening large groups of smokers, it cannot readily differentiate the ...
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Unenhanced whole-body MRI versus PET-CT for the detection of prostate cancer metastases after primary treatment [PDF]

, 2016
The aim of this study was to evaluate the accuracy of unenhanced whole-body MRI, including whole-body Diffusion Weighted Imaging (DWI), used as a diagnostic modality to detect  pathologic lymph nodes and skeletal metastases in patients with prostate ...
AL ANSARI, Najwa, Barchetti, Flavio, Barchetti, Giovanni, Catalano, Carlo, Marini, Alessandra, Megna, Valentina, Monti, M. L, Musio, D, Panebianco, Valeria, Stagnitti, Andrea, Tombolini, Vincenzo   +10 more
core  

Diagnostic accuracy of myocardial perfusion imaging with czt technology. Systemic review and meta-analysis of comparison with invasive coronary angiography [PDF]

, 2017
OBJECTIVES: This study sought to summarize the evidence on stress myocardial perfusion imaging (MPI) using cadmium-zinc-telluride (CZT) technology for the diagnosis of obstructive coronary artery disease (CAD). The CZT cameras are newly introduced, and
Biondi-Zoccai, Giuseppe, Frati, Giacomo, Iskandrian, Ami E., Nudi, Francesco, Peruzzi, Mariangela, Schillaci, Orazio   +5 more
core   +2 more sources

Imaging in vitreoretinal diagnostics

Indian Journal of Ophthalmology, 2013
Dear Friends, Greetings from the Editor's desk. I am privileged to introduce yet another monthly issue in this diamond jubilee year of our prestigious journal. This edition gives a fruitful insight into a wide range of subjects ranging from intraocular lenses to vein occlusion and retinal diagnostics.
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Multi-contrast imaging and digital refocusing on a mobile microscope with a domed LED array [PDF]

, 2015
We demonstrate the design and application of an add-on device for improving the diagnostic and research capabilities of CellScope--a low-cost, smartphone-based point-of-care microscope.
D'Ambrosio, Michael V., Fletcher, Daniel A., Gande, Aditya V., Patel, Hurshal S., Phillips, Zachary F., Rulison, Jared J., Sadras, Nitin, Switz, Neil A., Tian, Lei, Waller, Laura   +9 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source