Results 51 to 60 of about 1,679,146 (250)

Cytomorphology and Immunohistochemistry of Inflammatory Myofibroblastic Tumor: A Diagnostic Challenge

Archives of Medicine and Health Sciences
Background and Aim: The Inflammatory myofibroblastic tumor (IMT) is a tumor of intermediate grade with a low rate of metastasis. It often presents in paediatric age group and young adults.
Cherry Bansal, Neelam
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Diagnostic pitfalls: a case of prostate cancer and rectal cancer accompanied by prostate cancer invasion of the rectum

Diagnostic Pathology, 2022
Introduction Case of double primary cancer of the prostate and rectum is rare, prostate cancer involving the postoperative intestinal anastomotic mucosal tissue is even rarer.
Qiongxian Long, Ji Wu, Yong Peng, Xuqian Zhang, Xinya Liu, Huaping Chen   +5 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine:Part 1: Fit-for-Purpose Approach to Classification of Clinical Immunohistochemistry Biomarkers [PDF]

, 2017
The numbers of diagnostic, prognostic, and predictive immunohistochemistry (IHC) tests are increasing; the implementation and validation of new IHC tests, revalidation of existing tests, as well as the on-going need for daily quality assurance monitoring
Merdol Ibrahim, Clive R. Taylor, J. Han van Krieken, Torlakovic, Emina E, Swanson, Paul E., Nielsen, Soren, Glenn D. Francis, Krieken, J.H.J.M. van, Torlakovic, Emina E., D'Arrigo, Corrado, Gilks, C Blake, Nielsen, Søren; id_orcid, Hall, J.A., Jacqueline A. Hall, Hall, Jacqueline A, Corrado D’Arrigo, Francis, G.D., Cheung, Carol C., Hornick, J.L., Soren Nielsen, Dietel, M., Marchetti, Antonio, Marchetti, A., Taylor, Clive R., Cheung, Carol C, Torlakovic, E.E., Jason L. Hornick, Cheung, C.C., Taylor, C.R., Hornick, Jason L, IBRAHIM, M., van Krieken, J. Han, Nielsen, S., Gilks, C. Blake, Francis, Glenn, Dietel, Manfred, Vyberg, M., Swanson, P.E., Keith Miller, Gilks, C.B., Hornick, Jason L., Zhou, Xiaoge, Manfred Dietel, D'Arrigo, C., Miller, K., Antonio Marchetti, Zhou, X., Hall, Jacqueline A., Paul E. Swanson, Francis, Glenn D, Vyberg, Mogens, Xiaoge Zhou, Miller, Keith, Mogens Vyberg, Ibrahim, Merdol, Taylor, Clive R, van Krieken, J Han, Carol C. Cheung, Emina E. Torlakovic, Swanson, Paul E, C. Blake Gilks   +60 more
core   +2 more sources

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Summary of the diagnostic FISH, immunohistochemistry and the transcriptome analysis results.

, 2016
Summary of the diagnostic FISH, immunohistochemistry and the transcriptome analysis results.
Mirjam F. Mastik (2591206), Ed Schuuring (73120), Anthonie J. van der Wekken (2578264), Ali Saber (2578267), Klaas Kok (722695), T. Jeroen N. Hiltermann (2578261), Lisette J. Bosman (2591200), Wim Timens (41871), Harry J. M. Groen (101726), Anke van den Berg (80131), M. Martijn Terpstra (2591203)   +10 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Primary synovial sarcoma of thyroid: Diagnostic pitfalls and importance of immunohistochemistry

Indian Journal of Pathology and Microbiology
Synovial sarcoma in the head and neck region is relatively uncommon, and primary synovial sarcoma of the thyroid gland is extremely rare with only 19 reported cases in the English literature.
Rakesh Kumar Gupta, Sharmistha Chakravarty, Mehar Chand Sharma, Manish Kumar   +3 more
doaj   +1 more source