Results 91 to 100 of about 1,354,199 (345)

Molecular Testing for Acute Respiratory Tract Infections: Clinical and Diagnostic Recommendations From the IDSA’s Diagnostics Committee

Clinical Infectious Diseases, 2020
The clinical signs and symptoms of acute respiratory tract infections (RTIs) are not pathogen specific. Highly sensitive and specific nucleic acid amplification tests have become the diagnostic reference standard for viruses, and translation of bacterial
K. Hanson, M. Azar, R. Banerjee, Andrew Chou, R. Colgrove, C. Ginocchio, M. Hayden, Mark Holodiny, Seemalata Jain, S. Koo, Jaclyn Levy, T. Timbrook, A. Caliendo   +12 more
semanticscholar   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Access to Diagnostic Tests and Essential Medicines for Cardiovascular Diseases and Diabetes Care: Cost, Availability and Affordability in the West Region of Cameroon

PLoS ONE, 2014
Objective To assess the availability and affordability of medicines and routine tests for cardiovascular disease (CVD) and diabetes in the West region of Cameroon, a low-income setting.
A. Jingi, J. Noubiap, Arnold Ewane Onana, J. R. Nansseu, Binhuan Wang, S. Kingue, A. Kengne   +6 more
semanticscholar   +1 more source

Routine laboratory testing to determine if a patient has COVID‐19

Cochrane Database of Systematic Reviews, 2020
Background Specific diagnostic tests to detect severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and resulting COVID‐19 disease are not always available and take time to obtain results. Routine laboratory markers such as white blood cell count,
I. Stegeman, E. Ochodo, F. Guleid, G. Holtman, Bada Yang, C. Davenport, J. Deeks, J. Dinnes, S. Dittrich, Devy M. Emperador, L. Hooft, R. Spijker, Y. Takwoingi, A. Van den Bruel, Junfeng Wang, M. Langendam, J. Verbakel, M. Leeflang   +17 more
semanticscholar   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Application of Ultrasonography and Radiography in Detection of Hemothorax: a Systematic Review and Meta-Analysis

Emergency, 2016
Introduction: Hemothorax is one of the most prevalent injuries caused by thoracic traumas. Early detection and treatment of this injury is of utmost importance in prognosis of the patient, but there are still controversial debates on the diagnostic value
Vafa Rahimi-Movaghar, Mahmoud Yousefifard, Parisa Ghelichkhani, Masoud Baikpour, Abbas Tafakhori, Hadi Asady, Gholamreza Faridaalaee, Mostafa Hosseini, Saeed Safari   +8 more
doaj  

Reliability of Rapid Diagnostic Tests in Diagnosing Pregnancy-Associated Malaria in North-Eastern Tanzania. [PDF]

, 2012
Accurate diagnosis and prompt treatment of pregnancy-associated malaria (PAM) are key aspects in averting adverse pregnancy outcomes. Microscopy is the gold standard in malaria diagnosis, but it has limited detection and availability.
A Mayor, A Moody, A Muehlenbachs, A Salanti, AA Adegnika, Adrian JF Luty, AE Mnzava, AHD Kilian, AJ Umbers, Ali Salanti, AM de Oliveira, B Mmbando, C Wongsrichanalai, Caroline Pehrson, CE Shulman, CE Shulman, Christentze Schmiegelow, D Ishengoma, Daniel Andersen, Daniel TR Minja, Davis John, DP Mason, DR Bell, DRS Ishengoma, E Tjitra, F Bánhidy, F Mockenhaupt, FP Mockenhaupt, FP Mockenhaupt, G Snounou, H Reyburn, H Verhoef, HL Guyatt, IA McGregor, J Baker, J Lusingu, J Wooden, JM Tham, John PA Lusingu, JP Lusingu, JR Forney, K Källander, KA Bojang, LC Okell, LEG Mboera, LM Singer, M Amexo, M Dhorda, M Fried, M Fried, M Mayxay, M Mayxay, Martha Lemnge, Mayke Oesterholt, Michael Alifrangis, ML McMorrow, N Othnigué, NEER Singh, NJ White, P Bejon, P Mens, P Mens, Pamela A Magistrado, PE Duffy, Philippe Deloron, R Bǿdker, RW Steketee, S Gerstl, S Karl, S Schachterle, Stéphanie Boström, T Jelinek, TA VanderJagt, The United Republic of Tanzania, Thor Theander, TT Thomsen, V Batwala, WHO   +77 more
core   +2 more sources

Malaria rapid diagnostic tests in endemic settings.

Clinical Microbiology and Infection, 2013
Malaria rapid diagnostic tests (RDTs) are instrument-free tests that provide results within 20 min and can be used by community health workers. RDTs detect antigens produced by the Plasmodium parasite such as Plasmodium falciparum histidine-rich protein ...
J. Maltha, J. Maltha, P. Gillet, J. Jacobs   +3 more
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source