Diaphragm Dysfunction in Chronic Obstructive Pulmonary Disease [PDF]
American Journal of Respiratory and Critical Care Medicine, 2005 Hypercapnic respiratory failure because of inspiratory muscle weakness is the most important cause of death in chronic obstructive pulmonary disease (COPD). However, the pathophysiology of failure of the diaphragm to generate force in COPD is in part unclear.The present study investigated contractile function and myosin heavy chain content of diaphragm
Ottenheijm, Coen A.C. +7 more
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Early phrenic motor neuron loss and transient respiratory abnormalities following unilateral cervical spinal cord contusion [PDF]
, 2013 Contusion-type cervical spinal cord injury (SCI) is one of the most common forms of SCI observed in patients. In particular, injuries targeting the C3-C5 region affect the pool of phrenic motor neurons (PhMNs) that innervates the diaphragm, resulting in ...
Adriaens, Dominique +8 more
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Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury. [PDF]
, 2017 The therapeutic benefit of cell transplantation has been assessed in a host of central nervous system (CNS) diseases, including disorders of the spinal cord such as traumatic spinal cord injury (SCI).
Charsar, Brittany A. +2 more
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Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness [PDF]
, 2014 Muscle wasting and cachexia are important systemic manifestations of highly prevalent conditions including cancer. Inflammation, oxidative stress, autophagy, ubiquitin-proteasome system, nuclear factor (NF)-kB, and mitogen activated protein kinases (MAPK)
Bal, Elisa Dora +7 more
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Bortezomib partially protects the rat diaphragm from ventilator-induced diaphragm dysfunction* [PDF]
Critical Care Medicine, 2012 Controlled mechanical ventilation leads to diaphragmatic contractile dysfunction and atrophy. Since proteolysis is enhanced in the diaphragm during controlled mechanical ventilation, we examined whether the administration of a proteasome inhibitor, bortezomib, would have a protective effect against ventilator-induced diaphragm dysfunction.Randomized ...
Agten, A. +7 more
openaire +4 more sources
Local BDNF Delivery to the Injured Cervical Spinal Cord using an Engineered Hydrogel Enhances Diaphragmatic Respiratory Function. [PDF]
, 2018 We developed an innovative biomaterial-based approach to repair the critical neural circuitry that controls diaphragm activation by locally delivering brain-derived neurotrophic factor (BDNF) to injured cervical spinal cord.
Ghosh, Biswarup +8 more
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What every ICU clinician needs to know about the cardiovascular effects caused by abdominal hypertension [PDF]
, 2015 The effects of increased intra-abdominal pressure (IAP) on cardiovascular function are well recognized and include a combined negative effect on preload, afterload and contractility.
De Keulenaer, Bart L +2 more
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Arterial anatomy and arteriographic diagnosis of arteriogenic impotence [PDF]
, 1988 One hundred twenty-six bilateral selective arteriographic examinations of the iliopudendal vascular tree were performed after comprehensive multidisciplinary evaluation in patients with chronic erectile dysfunction.
Bähren, Wolfgang +4 more
core +1 more source
Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension. [PDF]
PLoS ONE, 2013 Pulmonary hypertension (PH) causes loss of body weight and inspiratory (diaphragm) muscle dysfunction. A model of PH induced by drug (monocrotaline, MCT) has been extensively used in mice to examine the etiology of PH.
Bumsoo Ahn +4 more
doaj +1 more source
Pulmonary outcomes following specialized respiratory management for acute cervical spinal cord injury: a retrospective analysis. [PDF]
, 2017 Study designRetrospective analysis.ObjectivesTo identify multivariate interactions of respiratory function that are sensitive to spinal cord injury level and pharmacological treatment to promote strategies that increase successful liberation from ...
Crew, JD +5 more
core +1 more source