Results 61 to 70 of about 19,952 (211)

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

The Influence of the Associated Inactivated Vaccine Against Infectious Rhinotracheitis and Bovine Viral Diarrhea on the Formation and Duration of Colostral Immunity in Kazakh Whiteheaded Calves

Vaccines
Objectives: This article presents a study evaluating the antibody levels against infectious bovine rhinotracheitis (IBR) and bovine viral diarrhea (BVD) in Kazakh Whiteheaded calves born to dams immunized with an experimental inactivated combined vaccine
Yerbol Bulatov, Alina Kurmasheva, Zhanat Amanova, Ruslan Abitaev, Zhanna Sametova, Asselya Kyrgyzbayeva, Zhanat Kondybaeva, Sholpan Turyskeldi, Abdurakhman Ussembay, Dariya Toktyrova, Dana Mazbayeva, Yeraly Shayakhmetov, Aslan Kerimbayev, Damir Khussainov, Ma Wentao, Aralbek Rsaliyev, Yergali Abduraimov   +16 more
doaj   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Outbreaks of pneumonia in beef calves associated with bovine viral diarrhea virus seroconversion and other respiratory pathogens

Journal of Veterinary Medical Research, 2005
The present study describes the clinical, serological and bacteriolological findings in calves from two beef herds experiencing outbreaks of pneumonia. The clinical signs were nasal discharge, cough, pyrexia and increased respiratory rates.
A. M. Khadr
doaj  

Virulence Markers in the 5′ Untranslated Region of Genotype 2 Bovine Viral Diarrhea Virus Isolates

Virology, 1998
Virulence markers to distinguish high from low virulence bovine viral diarrhea virus genotype 2 isolates have not been previously reported. The objective of this study was to identify virulence markers by evaluating the primary and secondary structures of the 5'-untranslated region of low and high virulence bovine viral diarrhea virus genotype 2 ...
Topliff, Christina L, Kelling, Clayton L
openaire   +2 more sources

No effects of noncytopathic bovine viral diarrhea virus type 2 on the reproductive tract of experimentally inoculated boars

Veterinary Microbiology, 2020
Bovine viral diarrhea virus (BVDV) infections in pigs may result in transient leukopenia, chronic gastroenteritis, septicemia, and hemorrhagic lesions. Both classical swine fever virus (CSF) and the atypical porcine pestivirus (APPV) are shed in the semen of infected boars. Because these viruses share conserved regions and present antigenic similarity,
Storino, Gabriel Yuri, Xavier, Eduarda Bellini, Mechler-Dreibi, Marina Lopes, Simonatto, Artur, Gatto, Igor Renan Honorato, Oliveira, Maria Emilia Franco, Pituco, Edviges Maristela, de Oliveira, Luís Guilherme   +7 more
openaire   +4 more sources

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Heat Shock Protein 70 in Cold-Stressed Farm Animals: Implications for Viral Disease Seasonality

Microorganisms
The seasonal patterns of viral diseases in farm animals present significant challenges to global livestock productivity, with cold stress emerging as a potential modulator of host–pathogen interactions.
Fanzhi Kong, Xinyue Zhang, Qi Xiao, Huilin Jia, Tengfei Jiang   +4 more
doaj   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Real Time Analysis of Bovine Viral Diarrhea Virus (BVDV) Infection and Its Dependence on Bovine CD46

Viruses, 2020
Virus attachment and entry is a complex interplay of viral and cellular interaction partners. Employing bovine viral diarrhea virus (BVDV) encoding an mCherry-E2 fusion protein (BVDVE2-mCherry), being the first genetically labelled member of the family ...
Christiane Riedel, Hann-Wei Chen, Ursula Reichart, Benjamin Lamp, Vibor Laketa, Till Rümenapf   +5 more
doaj   +1 more source