Results 91 to 100 of about 71,564 (304)

Amphibian: heart: atrial diastole

, 2010
It shows the dorsal view of an anuran’s heart. It highlights the ventricular systole and atrial diastole synchronismEducação Superior::Ciências Biológicas::Biologia GeralEnsino Médio::BiologiaEducação Superior::Ciências Agrárias::Medicina ...
Sebben, Antonio
core  

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD

Advanced Science, EarlyView.
This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu, Yufei Sun, Xinlei Wu, Haixia Chen, Shaocong Mo, Zichong Li, Yiwei Gong, Xiaoqian Shan, Yuanqi Li, Yaru Guan, Junqi Zhu, Han Yan, Min Du, Feng Wei, Peixin Ou, Ziyi Wang, Chenting Zhang, Lei Xu, Wenju Lu, Jian Wang, Kai Yang   +20 more
wiley   +1 more source

Amphibian: heart: atrial diastole

, 2014
It shows the dorsal view of an anuran’s heart. It highlights the ventricular systole and atrial diastole synchronismEducação Superior::Ciências Biológicas::Biologia GeralEnsino Médio::BiologiaEducação Superior::Ciências Agrárias::Medicina ...
Sebben, Antonio
core  

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source

Ca2+/calmodulin‐dependent protein kinase II and protein kinase G independently contribute to acutely enhance myocardial compliance with stretch

Physiological Reports
The heart constantly adapts to acute hemodynamic load by increasing contractility and stretch‐induced compliance (SIC). The latter involves titin phosphorylation, notably by cGMP‐dependent protein kinase (PKG).
André M. Leite‐Moreira, João Almeida‐Coelho, Inês Falcão‐Pires, André P. Lourenço, Adelino F. Leite‐Moreira   +4 more
doaj   +1 more source

Relationship between abnormal P-wave terminal force in lead V1 and left ventricular diastolic dysfunction in hypertensive patients: the LIFE study

Blood Pressure, 2017
Background: Abnormal P-wave terminal force in lead V1 (PTF-V1) is an ECG marker of increased left atrial (LA) volume, elevated LA filling pressures and/or LA systolic dysfunction.
Michael T. Tanoue, Sverre E. Kjeldsen, Richard B. Devereux, Peter M. Okin   +3 more
doaj   +1 more source

GWAS summary statistics for left-ventricular phenotypes at end-diastole

<h2>GWAS summary statistics for left-ventricular traits at end-diastole</h2> <p>These phenotypes were derived from 3D meshes of the left ventricle at end-diastole, which in turn were obtained via segmentation from cardiovascular ...
Bonazzola, Rodrigo
core   +1 more source

Modeling pressure-flow relations in cardiac muscle in diastole and systole

, 1997
Pressure-flow relations were calculated for a symmetrical, maximally dilated, crystalloid-perfused coronary vascular network embedded in cardiac muscle in (static) diastole and (static) systole at two muscle lengths: slack length and 90% of maximal ...
N. Westerhof, P. Sipkema, M. A. Vis
core   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source