Results 81 to 90 of about 71,564 (304)

Relaxation and diastole of the heart

, 1989
In the present review, we adopted the viewpoint of the physiologist looking at the global function of the heart, during relaxation and diastole, as an integrated muscle-pump system. We first focused our attention on properties of relaxation and diastole
S. U. Sys, D. L. Brutsaert
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

VARIABILITAS TEKANAN DARAH INTRADIALISIS PASIEN PENYAKIT GINJAL KRONIS DENGAN HEMODIALISIS BERKELANJUTAN

Majalah Biomorfologi, 2019
Background: Various of studies report there was a link between changes in blood pressure during hemodialysis and the level of patient’s morbidity and mortality.
Maulana Muhtadin Suryansyah, Mochammad Thaha, Budiono Budiono   +2 more
doaj   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

The times they are a-changin': Two-dimensional aortic valve measurements differ throughout diastole

, 2016
Introduction Diastolic aortic valve measurements are used to obtain weight-independent cardiac ratiometric indices. However, whether clinically important variations in valve measurements occur during diastole remains undetermined.
Rishniw, M., Dickson, D, Patteson, M., CAIVANO, DOMENICO   +3 more
core   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

The Health Profile of Students and Teachers in Madrasah Al Ihsan, Kecamatan Ciparay, Kabupaten Bandung

Pharmacology and Clinical Pharmacy Research
The prevalence of diabetes mellitus and hypertension in Indonesia is increasing both in low- and high-income communities. Therefore, health awareness should be started from a younger age for the prospective future generation.
Ellin Febrina, Irma E. Herawati, Indah S. Wahyuni, Aziiz M. Rusdianto, Rini Hendriani, Irma M. Puspitasari, Mutakin Mutakin, Eli Halimah, Sri A. Sumiwi, Jutti Levita   +9 more
doaj   +1 more source

The mediating role of the left ventricular mass index on the relationship between the fluid balance and left ventricular diastolic function in patients with chronic kidney disease [PDF]

Kidney Research and Clinical Practice
Background The pathophysiological mechanism of cardiovascular disease in patients with chronic kidney disease (CKD) is complicated. Mediation analysis is an important statistical tool for gaining insight into the complex mechanisms of exposure-outcome ...
Byoung-Geun Han, Jun Young Lee, Jae-Seok Kim, Jae-Won Yang, Sang Wook Park   +4 more
doaj   +1 more source

Patient-Specific Echo-Based Left Ventricle Models for Active Contraction and Relaxation Using Different Zero-Load Diastole and Systole Geometries

, 2019
A new modeling approach using two different zero-load geometries (diastole and systole) was introduced to properly model active contraction and relaxation for more accurate stress/strain calculations.
Di Xu, Jing Yao, Chun Yang, Longling Fan, Dalin Tang   +4 more
core   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source