Results 101 to 110 of about 70,280 (301)
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Advanced Science, EarlyView.Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
HUBUNGAN TEKANAN DARAH (DIASTOLE) TERHADAP PROFIL HDL DAN LDL PASIEN DIABETES MELITUS DENGAN RIWAYAT HIPERTENSI DI RUMAH SAKIT ISLAM JEMURSARI [PDF]
, 2019 Hipertensi menjadi salah satu tanda dari komplikasi diabetes mellitus. Pada hipertensi sering terjadi abnormalitas lipid yang berkaitan dengan aktifitas saraf simpatis yang mempengaruhi rangsangan dari resistensi insulin.
UMAMI, NAFA
core +1 more source
The Diastolic Oscillation Amplitude Used as an Arterial Aging Indicator
Vascular Health and Risk Management, 2023 Fernando M Clara,1,2 José Alfie,3 Adriana Scandurra,1 Mariana Fita2 1Instituto de Investigaciones Científicas y Tecnológicas en Electrónica, Universidad Nacional de Mar del Plata/ CONICET, Mar del Plata, Argentina; 2Unidad Cardiometabólica, Centro de ...
Clara FM, Alfie J, Scandurra A, Fita M
doaj
Heart International, 2006 Background. Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric LV hypertrophy (LVH) and impairment in diastolic function. We assess the relationship between LVH and invasive indexes of diastolic function. Methods.
Massimo Chiariello +5 more
doaj +1 more source
Printable Piezoresistive Hybrid Hydrogels Based on 2D MoS2 for Flexible Pulse Sensing
Advanced Science, EarlyView.Hybrid 1T‐MoS2‐based hydrogels are engineered through UV curing and 3D printing to achieve tunable electromechanical properties for wearable sensing. These soft architectures enhance mechanical stability and reproducible piezoresistive responses within the physiological pressure range.
Jenny Flores +18 more
wiley +1 more source
NOVEL UNDERSTANDING OF THE PHASIC STRUCTURE OF SYSTEMIC CIRCULATION
Российский кардиологический журнал, 2014 The article provides novel approach to the phasic structure of systemic circulation for rheovasogramms of upper and lower extremities, based upon neither geometrical description with visual evaluation of rheographic complexes, but upon genesis of their ...
A. A. Garanin, A. E. Ryabov
doaj +1 more source
Advanced Science, EarlyView.Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem +24 more
wiley +1 more source
GWAS summary statistics for left-ventricular phenotypes at end-diastole
<h2>GWAS summary statistics for left-ventricular traits at end-diastole</h2> <p>These phenotypes were derived from 3D meshes of the left ventricle at end-diastole, which in turn were obtained via segmentation from cardiovascular ...
Bonazzola, Rodrigo
core +1 more source
Advanced Science, EarlyView.MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han +24 more
wiley +1 more source
Hydrodynamics of Cardiac Diastole
, 2011 Left ventricular diastole (filling) is a complex process with many features and coupled compensatory mechanisms which coordinate to maintain optimal filling and ejection of the left ventricle.
Stewart, Kelley Christine
core