Results 101 to 110 of about 66,989 (314)

Topologically Structured PLLA Fibers With Stress Concentration Effects for Health Monitoring

Advanced Science, EarlyView.
In this study, a multi‐path strategy was developed to enhance the piezoelectric properties of PLLA fibers through the stress concentration effect. The optimized devices generate piezoelectric output up to 14 times that of pure PLLA fibers. This piezoelectric enhancement strategy offers a new approach for high‐performance piezoelectric devices, with ...
Longfei Li, Juwei Yang, Yiqian Wang, Qiao Yu, Zhenmin Fan, Chang Zhu, Ming Yin, Wei Hua, Zhou Li   +8 more
wiley   +1 more source

DPIV vector field for the straight end-to-side graft shortly after diastole for the excitation case. [PDF]

, 2018
Observe that the stagnation region highlighted in Fig 7A remains throughout the cycle. Also note the high shear in the toe region even for low flow rates during diastole.
Timothy Wei (4885048), Gary B. Nackman (4885045), Chia Min Leong (4885042)   +2 more
core   +1 more source

The mediating role of the left ventricular mass index on the relationship between the fluid balance and left ventricular diastolic function in patients with chronic kidney disease [PDF]

Kidney Research and Clinical Practice
Background The pathophysiological mechanism of cardiovascular disease in patients with chronic kidney disease (CKD) is complicated. Mediation analysis is an important statistical tool for gaining insight into the complex mechanisms of exposure-outcome ...
Byoung-Geun Han, Jun Young Lee, Jae-Seok Kim, Jae-Won Yang, Sang Wook Park   +4 more
doaj   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Origin of regional pressure gradients in the left ventricle during early diastole [PDF]

, 1995
Left ventricular (LV) pressure (P)-diameter, LVP-area, or LVP-volume relationships used to evaluate LV diastolic function assume uniform LV wall motion and constant LVP.
O. E. Pajaro, M. P. Feneley, S. D. Nikolic, J. S. Rankin, E. L. Yellin   +4 more
core   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Simultaneous 3D aortic lumen and vessel wall imaging at 0.55 T at either systole or diastole [PDF]

PurposeTo evaluate the feasibility of a novel, non-contrast enhanced, 3D, simultaneous bright-blood, and black-blood sequence (iT2prep-BOOST) for aortic imaging at 0.55 T at either systole or diastole.
Prieto Vásquez, Claudia, Prieto, Claudia; id_orcid, Castillo Passi, Carlos, Fotaki, Anastasia, Botnar, René M; id_orcid, Kunze, Karl P., Castillo-Passi, Carlos, Littlewood, Simon; id_orcid, Paredes, Matias, Kunze, Karl P, Paredes Gálvez, Matías Ignacio, Botnar, René Michael, Littlewood, Simon   +12 more
core   +1 more source

VORTEX DYNAMICS IN THE LEFT VENTRICLE DURING DIASTOLE UNDER EDGE-TO-EDGE REPAIR [PDF]

, 2020
INTRODUCTION The edge-to-edge repair (ETER) is one of the mitral valve (MV) repair techniques frequently used in MV disease treatment. This technique restores valve competence by the suturing of the free edges of the leaflets either in the central ...
Zhaoming He, Yingying Hu, Liang Shi
core  

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, EarlyView.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source