Arthritis &Rheumatology, EarlyView.Objective To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial. Methods A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational ...
Stefano Di Donato +9 more
wiley +1 more source
Subclinical myocardial disease by cardiac magnetic resonance imaging and spectroscopy in healthy HIV/Hepatitis C virus-coinfected persons. [PDF]
, 2017 Objective The contribution of hepatitis C virus (HCV) infection to the risk of heart failure in human immunodeficiency virus (HIV)-coinfected persons is unknown.
Ambale-Venkatesh, Bharath +9 more
core +2 more sources
The Relationship between High Sensitive C-reaction Protein (hs-CRP) and Diastolic Heart Function in Diabetes Mellitus Type II [PDF]
, 2017 Among several inflammatory markers, high sensitive C-reaction protein (hs-CRP) is outstandingly observed in diabetic individuals. Serum hs-CRP is the main marker of inflammation whose levels independently predict the risk of cardiovascular events, and it
Aslan Mosavi, Elham Elhamdoost, Behrang Kazeminezhad, Samiramis Ghavam, Mohammad Reza Hafezi
core +1 more source
Association of PET-measured myocardial flow reserve with echocardiography-estimated pulmonary artery systolic pressure in patients with hypertrophic cardiomyopathy [PDF]
, 2019 BackgroundPulmonary hypertension (PH) is a known complication of HCM and is a strong predictor of mortality. We aim to investigate the relationship between microvascular dysfunction measured by quantitative PET and PH in HCM patients.MethodsEighty-nine ...
Leal, Jeffrey P +6 more
core +3 more sources
Estimation of Cardiac Valve Annuli Motion with Deep Learning [PDF]
arXiv, 2020 Valve annuli motion and morphology, measured from non-invasive imaging, can be used to gain a better understanding of healthy and pathological heart function. Measurements such as long-axis strain as well as peak strain rates provide markers of systolic function.
arxiv
Novel pathways of heart failure with preserved ejection fraction [PDF]
, 2016 INTRODUCTION: Diastolic heart failure (HF) i.e., HF with preserved ejection fraction (HFpEF) accounts for ~50% of all clinical HF presentations; but unlike systolic HF i.e., HF with reduced ejection fraction (HFrEF), there are no evidenced based ...
Li, Shanpeng
core +1 more source
Prediction of Turbulent Shear Stresses through Dysfunctional Bileaflet Mechanical Heart Valves using Computational Fluid Dynamics [PDF]
arXiv, 2018 There are more than 300,000 heart valves implanted annually worldwide with about 50% of them being mechanical valves. The heart valve replacement is often a common treatment for severe valvular disease. However, valves may dysfunction leading to adverse hemodynamic conditions.
arxiv
Cardiovascular function changes following lung resection: a computational model to compare afterload increase and contractility loss mechanisms [PDF]
arXivFunctional limitation after lung resection surgery has been consistently documented in clinical studies, and right ventricle (RV) dysfunction has been hypothesized as a contributing reason. However, the mechanisms of RV dysfunction after lung resection remain unclear, particularly whether change in afterload or contractility is the main cause.
arxiv
On a systolic inequality for closed magnetic geodesics on surfaces [PDF]
arXiv, 2019 We apply a local systolic-diastolic inequality for contact forms and odd-symplectic forms on three-manifolds to bound the magnetic length of closed curves with prescribed geodesic curvature (also known as magnetic geodesics) on an oriented closed surface. Our results hold when the prescribed curvature is either close to a Zoll one or large enough.
arxiv
Therapeutic Effect of Targeting Branched-Chain Amino Acid Catabolic Flux in Pressure-Overload Induced Heart Failure. [PDF]
, 2019 Background Branched-chain amino acid (BCAA) catabolic defect is an emerging metabolic hallmark in failing hearts in human and animal models. The therapeutic impact of targeting BCAA catabolic flux under pathological conditions remains understudied ...
Chen, Mengping +8 more
core +1 more source