Results 31 to 40 of about 86,598 (299)

A novel inhaled anesthesia technique for concurrent direct laryngoscopy in rats

Animal Models and Experimental Medicine, EarlyView.
Our novel nose cone anesthetic technique allows the use of gas anesthesia during concurrent direct laryngoscopy. Inhaled anesthesia not only has a better safety profile for rats, but also increases lab efficiency when compared to injectable anesthesia. Abstract The current anesthetic standard for laryngoscopy in rats utilizes injectable intraperitoneal
Corinne Negvesky, Amin Mirzaaghasi, Eric M. Smith, Ashley E. Kita   +3 more
wiley   +1 more source

Intranasal Seletracetam in a Patient with Reading Epilepsy: First‐in‐Human Use to Prevent Reflex Seizures

Annals of Neurology, EarlyView.
We report the first human use of intranasal seletracetam (SEL) to prevent reflex seizures. A patient with epilepsy with reading‐induced seizures on levetiracetam (3,000 mg/day) continued to experience reading‐induced focal seizures with preserved consciousness.
Matthias J. Koepp, Kai‐Nicolas Poppert, Thomas Felder, Aljoscha Thomschewski, Sandra Lafenthaler, Pavel Klein, Alexander Rotenberg, Wolfgang Löscher, Chris Rundfeldt, Eugen Trinka   +9 more
wiley   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Psychoactive prescription drug use and misuse in patients on opioid agonist treatment

British Journal of Clinical Pharmacology, EarlyView.
Aims To identify the patterns and trends in prescription drug use and misuse in patients on opioid agonist treatment. Methods We used data from the OPPIDUM programme, which collects data from patients attending substance abuse treatment facilities. Data collected include use of psychoactive prescription drugs in the past week.
Thomas Soeiro, Clémence Lacroix, Élisabeth Jouve, Élisabeth Frauger, Maryse Lapeyre‐Mestre, Joëlle Micallef   +5 more
wiley   +1 more source

Comparison of Effectiveness and Side Effects of Diazepam versus Midazolam Administration for Conscious Sedation in Patients Who Underwent Cataract Surgery

Archives of Anesthesia and Critical Care, 2019
Background: The purpose of this study was to compare the effectiveness and side effects of diazepam and midazolam administration for conscious sedation in subjects who undergoing cataract surgery.
Mehdi Sanatkar, Mehrdad Shorooghi, Mohammad Sadegh Sanie   +2 more
doaj   +1 more source

Anxiolytic activity of Berberis aristata root extract in mice

BLDE University Journal of Health Sciences, 2020
BACKGROUND: Anxiety is a common emotional response in humans and it is one of most common psychiatric illnesses. Interest in herbal drugs is growing nowadays for the optimum treatment of anxiety. The aim of the present study was to explore the anxiolytic
Divya Goel
doaj   +1 more source

Drug poisonings following bariatric surgery: Case series report

British Journal of Clinical Pharmacology, EarlyView.
Bariatric surgery alters gastrointestinal anatomy and physiology, which likely impacts upon oral medication absorption. Drug‐ and alcohol‐related deaths in this population are being increasingly reported; however, toxicological detail is lacking. Using data reported to the National Programme on Substance Use Mortality, we identified 18 deaths in people
Eman Mshari, Fannie LaJeunesse‐Trempe, Stephen Morley, Caroline Copeland   +3 more
wiley   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Sedative Effects of Intraperitoneal Diazepam in Mice

International Journal of Integrated Health Sciences, 2023
Objectives: To determine the effectiveness of Diazepam in comparison with Phenobarbital. Methods: Twenty-seven male Swiss Webster mice were used and randomly divided into three groups of negative control (NS), positive control (Phenobarbital), and ...
Marsha Vania, Shinta Dewi Permata Sari, Bambang Siswitono, Endin Nokik Stujanna   +3 more
doaj  

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source