Results 71 to 80 of about 83,280 (287)
Sedative Effects of Intraperitoneal Diazepam in Mice
International Journal of Integrated Health Sciences, 2023 Objectives: To determine the effectiveness of Diazepam in comparison with Phenobarbital. Methods: Twenty-seven male Swiss Webster mice were used and randomly divided into three groups of negative control (NS), positive control (Phenobarbital), and ...
Marsha Vania +3 more
doaj
GABAA Receptor α Subunits Differentially Contribute to Diazepam Tolerance after Chronic Treatment
PLoS ONE, 2012 Background Within the GABAA-receptor field, two important questions are what molecular mechanisms underlie benzodiazepine tolerance, and whether tolerance can be ascribed to certain GABAA-receptor subtypes.
C. Vinkers +7 more
semanticscholar +1 more source
Lacosamide decreases neonatal seizures without increasing apoptosis
Epilepsia, Volume 63, Issue 12, Page 3051-3065, December 2022., 2022 Abstract Objective Many seizing neonates fail to respond to first‐line anticonvulsant medications. Phenobarbital, an allosteric modulator of γ‐aminobutyric acid type A (GABAA) receptors, has low efficacy in treating neonatal seizures and causes neuronal apoptosis. Nonetheless, it is one of the most used anticonvulsants in this age group.
Rachel L. Langton +4 more
wiley +1 more source
Structure of Heteropentameric GABAA Receptors and Receptor-Anchoring Properties of Gephyrin
Frontiers in Molecular Neuroscience, 2019 γ-Aminobutyric acid type A receptors (GABAARs) mediate the majority of fast synaptic inhibition in the central nervous system (CNS). GABAARs belong to the Cys-loop superfamily of pentameric ligand-gated ion channels (pLGIC) and are assembled from 19 ...
Vikram Babu Kasaragod +1 more
doaj +1 more source
Epileptic Disorders, EarlyView.Abstract Startle‐induced seizure is a rare type of reflex seizure triggered by unexpected sensory stimuli that often occurs in children with early acquired cerebral lesions or brain malformations. We report a unique case of adult‐onset epilepsy with startle‐induced seizures.
Kazutoshi Konomatsu +12 more
wiley +1 more source
Diazepam induced oxidative DNA damage in cultured human lymphocytes
Journal of King Saud University: Science, 2018 Diazepam is a benzodiazepine compound that is mainly used for anxiety, muscle spasms, seizures and insomnia. Several studies have shown that long-term Diazepam treatment is associated with oxidative stress. In this study, the possible genotoxic effect of
Mohammad Azab +3 more
doaj
Activated Carbon-Based System for the Disposal of Psychoactive Medications
Pharmaceutics, 2016 The misuse and improper disposal of psychoactive medications is a major safety and environmental concern. Hence, the proper disposal of these medications is critically important.
Yang Song +4 more
doaj +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective Status epilepticus (SE) is a condition of neurological emergency, which precipitates various functional and morphological changes in the brain. Due to the risk of drug resistance associated with SE, this study aimed to evaluate a multitargeted approach to treat SE by combining clinically used antiseizure drugs. Methods In this study,
Sana Javaid +7 more
wiley +1 more source
Clinical Case Reports, 2023 Stiff Person Syndrome (SPS), a progressive Central Nervous System disorder is accompanied by progressive muscle rigidity, hyperreflexia, and spasms mainly in truncal and proximal leg muscles mainly associated with autoimmune disorders.
Sanjeev Kharel +9 more
doaj +1 more source