Results 91 to 100 of about 6,933 (191)

Rh(III)-Catalyzed Double Annulation of 3-Phenyl-1,2,4-oxadiazoles with 2-Diazo-1,3-diketones: Access to Pyran-Fused Isoquinolines

Molecules
Efficient access to pyranoisoquinoline derivatives via rhodium-catalyzed double C-H functionalization of phenyl oxadiazoles and diazo compounds has been developed.
Enshen Zhang, Mei Sun, Lvlv Gao
doaj   +1 more source

Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley   +1 more source

Methyl on the Bridge: 2‐Methyl Propellane as Precursor for 1,3‐Substituted 2‐Methylated Bicyclo[1.1.1]Pentanes

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
The synthesis of 2‐methyl propellane and its conversion to various 1,2‐ and 1,2,3‐di‐ and trisubstituted bicyclopentanes is reported. Abstract Bicyclo[1.1.1]pentanes (BCPs) have emerged as isosteric replacements for mono‐ and para‐substituted benzene rings in medicinal and materials applications, involving substitution at the BCP bridgehead (1,3 ...
Sean R. Verschaeve, Mariana Gomes Manso, Tibo Van Eeckhoorn, Mark E. Light, Bruno Linclau   +4 more
wiley   +1 more source

Investigating the Inhibitory Properties of Diazo and Pyrazole‐Carboxamide‐Linked Benzenesulfonamides Against Carbonic Anhydrase Isoforms I, II, IX, and XII

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Hybrid diazo‐ and pyrazole‐carboxamide benzenesulfonamides emerge as highly potent and selective inhibitors of tumor‐associated carbonic anhydrases. A 3,4‐dichloro‐substituted derivative achieves sub‐2 nM inhibition of hCA IX and displays promising anticancer activity, revealing a valuable scaffold for the development of next‐generation cancer‐targeted
Suleyman Akocak, Nebih Lolak, Andrea Ammara, Gökçenur Gürbüz, Ibrahim Bozgeyik, Demet Taşdemir, Hamada Hashem, Stefan Bräse, Claudiu T. Supuran   +8 more
wiley   +1 more source

Rh(III)-catalyzed chelation-assisted C–H activation/annulation of 2-arylimidazolines with cyclic diazo-1,3-dicarbonyl compounds: a novel approach to tetracyclic annulated derivatives of 2,3-dihydroimidazo[2,1-a]isoquinoline

Beilstein Journal of Organic Chemistry
2-Arylimidazolines were annulated with cyclic diazo-1,3-dicarbonyl compounds under Rh(III)-catalysis for the first time. The developed general and efficient approach based on CH-activation allowed the efficient preparation of five novel types of ...
Ivan Lyutin, Grigory Kantin, Olga Bakulina, Dmitry Dar'in   +3 more
doaj   +1 more source

Asymmetric Donor–Acceptor 2,7-Disubstituted Fluorenes and Their 9-Diazoderivatives: Synthesis, Optical Spectra and Photolysis

Molecules
In a search for dyes photoactivatable with visible light, fluorenes with substituents at positions 2 and 7 were prepared, and their absorption and emission spectra were studied.
Andrei I. Savchenko, Vladimir N. Belov, Mariano L. Bossi, Stefan W. Hell   +3 more
doaj   +1 more source

Protocol for aqueous synthesis of bioactive quaternary ammonium betaine derivatives under blue LED

STAR Protocols
Summary: Quaternary ammonium compounds exhibit diverse applications as antibiotics, as surfactants, in paper industries, in sewage treatment, and in aquaculture.
Suchismita Rath, Subhabrata Sen
doaj   +1 more source

Imine Directed Cp*Rh^III -Catalyzed N-H Functionalization and Annulation with Amino Amides, Aldehydes, and Diazo Compounds. [PDF]

Angew Chem Int Ed Engl, 2023
Zoll AJ, Molas JC, Mercado BQ, Ellman JA.   +3 more
europepmc   +1 more source

SuFExable NH-Pyrazoles via 1,3-Dipolar Cycloadditions of Diazo Compounds with Bromoethenylsulfonyl Fluoride. [PDF]

J Org Chem, 2022
Yamanushkin P, Kaya K, Feliciano MAM, Gold B.   +3 more
europepmc   +1 more source

B(C₆F₅)₃-Catalyzed Diastereoselective and Divergent Reactions of Vinyldiazo Esters with Nitrones: Synthesis of Highly Functionalized Diazo Compounds. [PDF]

Org Lett, 2023
Stefkova K, Guerzoni MG, van Ingen Y, Richards E, Melen RL.   +4 more
europepmc   +1 more source