Results 111 to 120 of about 1,703,017 (234)

Isoxazolium N-ylides and 1-oxa-5-azahexa-1,3,5-trienes on the way from isoxazoles to 2H-1,3-oxazines

Beilstein Journal of Organic Chemistry, 2014
Theoretical and experimental studies of the reaction of isoxazoles with diazo compounds show that the formation of 2H-1,3-oxazines proceeds via the formation of (3Z)-1-oxa-5-azahexa-1,3,5-trienes which undergo a 6π-cyclization.
Alexander F. Khlebnikov, Mikhail S. Novikov, Yelizaveta G. Gorbunova, Ekaterina E. Galenko, Kirill I. Mikhailov, Viktoriia V. Pakalnis, Margarita S. Avdontceva   +6 more
doaj   +1 more source

The Amazonian “Bacuri” Seeds Butter (Platonia insignis Mart.) Improves Ex Vivo Aortic Vascular Dysfunction and In Vivo Oxidative Stress in L‐NAME‐Treated Rats

Phytochemicals in Food and Medicine, Volume 1, Issue 4, December 2026.
Industrialised bacuri seed butter (Platonia insignis Mart.) exhibited antioxidant and vasorelaxant effects, improving vascular reactivity and oxidative stress biomarkers in hypertensive rats. These findings highlight MIB as a promising natural product for mitigating hypertension‐associated vascular dysfunction and oxidative stress.
Maisa Gomes da Silva, Simone Kelly Rodrigues Lima, Angélica Gomes Coelho, Mariely Mendes Furtado, Andressa Amorim dos Santos, Ana Victória da Silva Mendes, Izabel Costa Barros, Isadora Basilio Meneses Bezerra, Ana Karolinne da Silva Brito, Benedito Pereira de Sousa Neto, Oskar Almeida Silva, Guilherme Antônio Lopes de Oliveira, Waldilleny Ribeiro de Araújo Moura, Maria do Carmo de Carvalho e Martins, Massimo Lucarini, Alessandra Durazzo, Daniel Dias Rufino Arcanjo   +16 more
wiley   +1 more source

Lightening Diazo Compounds? [PDF]

ACS Sustainable Chemistry & Engineering, 2021
Jakub Durka, Joanna Turkowska, Dorota Gryko   +2 more
openaire   +1 more source

A novel one-pot method for the preparation of pyrazoles by 1,3-dipolar cycloadditions of diazo compounds generated in situ

, 2003
A convenient one-pot procedure for the preparation of pyrazoles by 1,3-dipolar cycloaddition of diazo compounds generated in situ has been developed. Diazo compounds derived from aldehydes were reacted with terminal alkynes to furnish regioselectively 3 ...
Aggarwal, VK, Vicente-Fidalgo, Javier, Bonnert, RV   +2 more
core   +1 more source

A designer protein binder of KRAS enables exogenous protein degradation

Protein Science, Volume 35, Issue 12, December 2026.
Abstract Targeted protein degradation has emerged as a powerful strategy for modulating intracellular proteins, particularly those lacking traditional small‐molecule binding pockets. While protein‐based degraders expand this approach to undruggable targets, they typically require intracellular expression in target cells, limiting their utility as ...
Aniekan Okon, Keith M. Cheah, Oscar J. Molina, Gabriel Saenz, K. Dane Wittrup, Ronald T. Raines   +5 more
wiley   +1 more source

Rh(III)-Catalyzed Double Annulation of 3-Phenyl-1,2,4-oxadiazoles with 2-Diazo-1,3-diketones: Access to Pyran-Fused Isoquinolines

Molecules
Efficient access to pyranoisoquinoline derivatives via rhodium-catalyzed double C-H functionalization of phenyl oxadiazoles and diazo compounds has been developed.
Enshen Zhang, Mei Sun, Lvlv Gao
doaj   +1 more source

A Novel One-Pot Method for the Preparation of Pyrazoles by 1,3-Dipolar Cycloadditions of Diazo Compounds Generated in Situ

, 2016
A convenient one-pot procedure for the preparation of pyrazoles by 1,3-dipolar cycloaddition of diazo compounds generated in situ has been developed. Diazo compounds derived from aldehydes were reacted with terminal alkynes to furnish regioselectively 3 ...
Javier de Vicente (1534099), Varinder K. Aggarwal (1363332), Roger V. Bonnert (2730049)   +2 more
core   +1 more source

Synthesis of Aminocyclopropanes by Redox‐Neutral Aminoalkylation

Angewandte Chemie International Edition, Volume 65, Issue 45, 2 November 2026.
Aminocyclopropane synthesis by hydroaminoalkylation utilizing cheap, readily available starting materials is presented, offering orthogonality to commonly used methods and allowing broad functional‐group tolerance. Solvent‐mediated conditions enable the reaction of a pre‐formed hemiaminal with alkenes and alkynes.
Gwyndaf A. Oliver, Konstantin Günther, Chiara Sebastianelli‐Schoditsch, Sophie Woolford, Iina Ludwig, Harald H. Sitte, Nuno Maulide   +6 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, Volume 20, Issue 11, Page 2637-2646, November 2026.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Synthesis of oxazole and furan derivatives via Rh₂(OAc)₄-catalyzed C≡X bond insertion of cyclic 2-diazo-1,3-diketones with nitriles and arylacetylenes

, 2018
A convenient and efficient procedure for the synthesis of 2-substituted-6,7-dihydrobenzo[d]oxazol-4(5H)-ones and 2-aryl-6,7-dihydrobenzofuran-4(5H)-ones through a Rh2(OAc)4-catalyzed C≡X (X = N, C) insertion of cyclic 2-diazo-1,3-diketones with nitriles ...
Yongjia Shang (556386), Chenli Fan (5909477), Xinwei He (556381), Yin Zuo (556384)   +3 more
core   +1 more source