Results 61 to 70 of about 6,752 (176)

Phosphoenolpyruvate carboxykinase 2 activation of the AMPK–CEBPB axis to enhance glutamine utilization to promote glycolysis and malignant behavior in adenocarcinomas cells under glucose deprivation

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
Glucose deprivation is a key characteristic of the tumor microenvironment. In this study, we verified through in vitro experiments that phosphoenolpyruvate carboxykinase 2 (PCK2) upregulates solute carrier family 38 member 2 (SLC38A2) via the AMPK–CEBPB axis, thereby enhancing glutamine utilization in A549 cells, which in turn promotes glycolysis and ...
Libo Ruan, Kewang Xu, Wenjun Zeng, Ling Xiao, Minjun Zhao, Haiyan Zhang   +5 more
wiley   +1 more source

Triphenyl{(E)-4-[4-(phenyldiazenyl)phenyl]-4H-1,2,4-triazol-1-yl}boron

Acta Crystallographica Section E, 2009
In the title compound, C32H26BN5 or [(C14H11N5)B(C6H5)3], the B atom is approximately tetrahedrally coordinated. The diazo unit is in a trans conformation, which is generally more stable than a cis one for aromatic azo compounds.
Daisuke Urakami, Katsuya Inoue, Shinya Hayami   +2 more
doaj   +1 more source

Sulfur Ylides in Skeletal‐Editing—Ring Expansion Reactions

Helvetica Chimica Acta, Volume 109, Issue 3, March 2026.
Sulfur ylides (S‐ylides) are emergent diazo surrogates that enable skeletal editing and ring expansion with safer handling and broad functional group tolerance. This perspective covers pioneer works and highlights recent advances in the field, while outlining key challenges and future directions that may redefine the role of S‐ylides in modern ...
Arsala Kamal, Olaf Tjabben, Ana Matošević, Olga García Mancheño   +3 more
wiley   +1 more source

Genome Mining for Diazo-Synthesis-Related Genes in Streptomyces sp. CS057 Unveiled the Cryptic Biosynthetic Gene Cluster crx for the Novel 3,4-AHBA-Derived Compound Crexazone 2

Biomolecules
Natural products play a crucial role in drug development, addressing the escalating microbial resistance to antibiotics and the treatment of emerging diseases. Progress in genome sequencing techniques, coupled with the development of bioinformatics tools
Laura Prado-Alonso, Suhui Ye, Ignacio Pérez-Victoria, Ignacio Montero, Pedro Riesco, Francisco Javier Ortiz-López, Jesús Martín, Carlos Olano, Fernando Reyes, Carmen Méndez   +9 more
doaj   +1 more source

Original Reactivity of ?-Diazo-?- ketoesters Catalyzed by CpRu Complexes

CHIMIA, 2014
Using ?-diazo-?-ketoesters as reagents and combinations of CpRu fragments and diimine ligands as catalysts, a series of original transformations have been obtained that can be rationalized by the formation of metal carbenes and metal-bound ylide
Cecilia Tortoreto, Thierry Achard, Martina Austeri, Walid Zeghida, Jérôme Lacour   +4 more
doaj   +1 more source

A Unique Intercellular Feedforward Loop From HK1 to TGF‐β1 Promotes the Progression of Hepatocellular Carcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Hepatocellular carcinoma (HCC) typically emerges in a fibrotic premalignant liver milieu, and hepatic stellate cells (HSCs) represent the predominant cell subtype implicated in hepatic fibrosis. The crosstalk between HCC cells and HSCs has been demonstrated to affect HCC progression.
Qi‐tao Chen, Qiao‐ling Huang, De‐yi Feng, Wen‐xiu Zhao, Zhi‐yuan Zhang, Zhi‐hong Jiang, Ming‐zhi Han, Shui‐shun Chen, Yi Zhang, Qiao Wu, Hang‐zi Chen   +10 more
wiley   +1 more source

Degradation of Dyes by Fungi: A Bibliometric Study and Bibliographic Review

Environmental Quality Management, Volume 35, Issue 3, Spring 2026.
ABSTRACT The degradation of dyes from textile effluents is considered a major challenge due to their high potential for environmental contamination and health risks due to their toxicity. In this sense, the use of fungi for the degradation of these compounds is reported in the literature as an ecological alternative with great potential.
Antonio Marcelo Magalhães Gomes, Sara Maria Paula da Rocha Rodrigues, Kelly de Araújo Rodrigues Pessoa, Gloria Maria Marinho Silva, Marcus Vinicius Freire Andrade   +4 more
wiley   +1 more source

Isoxazolium N-ylides and 1-oxa-5-azahexa-1,3,5-trienes on the way from isoxazoles to 2H-1,3-oxazines

Beilstein Journal of Organic Chemistry, 2014
Theoretical and experimental studies of the reaction of isoxazoles with diazo compounds show that the formation of 2H-1,3-oxazines proceeds via the formation of (3Z)-1-oxa-5-azahexa-1,3,5-trienes which undergo a 6π-cyclization.
Alexander F. Khlebnikov, Mikhail S. Novikov, Yelizaveta G. Gorbunova, Ekaterina E. Galenko, Kirill I. Mikhailov, Viktoriia V. Pakalnis, Margarita S. Avdontceva   +6 more
doaj   +1 more source

Site Selectivity in Pd-Catalyzed Reactions of α-Diazo-α-(methoxycarbonyl)acetamides: Effects of Catalysts and Substrate Substitution in the Synthesis of Oxindoles and β-Lactams

Molecules, 2019
The Pd-catalyzed intramolecular carbene C−H insertion of α-diazo-α-(methoxycarbonyl)acetamides to prepare oxindoles as well as β-lactams was studied.
Daniel Solé, Ferran Pérez-Janer, Arianna Amenta, M.-Lluïsa Bennasar, Israel Fernández   +4 more
doaj   +1 more source

Diels–Alder Cycloaddition of N-Azobenzene Maleimides with Furan and Electrochemical Study of Redox Reactions

Reactions
This work reports the synthesis of aminoazobenzene compounds derived from 3,5-dimethylaniline (1a–1f) via a diazo-coupling reaction with aromatic amines.
David Fernando Venegas-Villalvazo, David Abraham Figueroa-Hernández, Armando Pineda-Contreras, José Manuel Flores-Alvarez, Héctor García-Ortega, Juan Saulo González-González   +5 more
doaj   +1 more source