One-pot oximation–Beckmann rearrangement of ketones and aldehydes to amides of industrial interest: Acetanilide, caprolactam and acetaminophen [PDF]
, 1924 High yielding one-pot oximation–Beckmann rearrangement of ketones to amides in ktrifluoroacetic acid has been conducted on several ketones and aldehydes. The substrate reactivity showed to depend on both oximation and Beckmann rearrangement reaction rate.
Arico', Fabio +5 more
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Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic application
Brazilian Journal of Pharmaceutical Sciences, 2010 To develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS).
Demétrius Fernandes do Nascimento +11 more
doaj +1 more source
Butyrylcholinesterase Genetic Variants: Association with Cocaine Dependence and Related Phenotypes [PDF]
, 2013 Objective: the search for genetic vulnerability factors in cocaine dependence has focused on the role that neuroplasticity plays in addiction. However, like many other drugs, the ability of an individual to metabolize cocaine can also influence ...
Guindalini, Camila +6 more
core +3 more sources
Calcium in Renal Cells. Modulation of Calcium-dependent Activation of Phospholipase \(A_2\). [PDF]
, 2011 Calcium has been implicated as a regulatory factor in many physiological and pathophysiological processes in the renal cell. Under physiological conditions, the cytosolic free calcium concentration is maintained at approximately 100 nM.
Bonventre, Joseph Vincent
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Dibucaine Inhibition of Serum Cholinesterase [PDF]
BMB Reports, 2003 The dibucaine number (DN) was determined for serum cholinesterase (EC 3.1.1.8, SChE) in plasma samples. The ones with a DN of 79-82 were used, because they had the "usual" SChE variant. The enzyme was assayed colorimetrically by the reaction of 5,5'-dithiobis-[2-nitrobenzoic acid] (DTNB) with the free sulfhydryl groups of thiocholine that were produced
openaire +2 more sources
Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella [PDF]
, 2015 Axonemal dyneins are the molecular motors responsible for the beating of cilia and flagella. These motors generate sliding forces between adjacent microtubule doublets within the axoneme, the motile cytoskeletal structure inside the flagellum.
Geyer, Veikko +4 more
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NDP Kinase Moves into Developing Primary Cilia [PDF]
, 2004 Inmunofluorescence staining of murine NIH3T3 fibroblasts grown at high density shows that conventional nucleoside diphosphate (NDP) kinases A and B localize to a sensory organelle, the primary cilium.
Gallagher, Betty C. +3 more
core +2 more sources
Metabolism of dibucaine. II. Disposition and metabolism of dibucaine in rats.
Journal of Pharmacobio-Dynamics, 1989 The disposition and metabolism of dibucaine were studied in rats. After intraperitoneal administration of 3H-labelled dibucaine, the blood concentration of total radioactivity reached a maximum at 10 min and declined thereafter, with a biphasic curve having half-lives of 37.7 min and 11.2 h. Radioactivity in the tissues after administration was high in
K, Igarashi, F, Kasuya, M, Fukui
openaire +3 more sources
Introducing the microbiome into Precision Medicine [PDF]
, 2016 © The Author(s), 2016. This is the author's version of the work and is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Trends in Pharmacological Sciences 38 (2017): 81-91, doi:10.1016/j ...
Gilbert, Jack A., Kuntz, Thomas M.
core +1 more source
Phosphoproteins associated with cyclic nucleotide stimulation of ciliary motility in Paramecium [PDF]
, 1990 Permeabilized, MgATP-reactivated cells of Paramecium (models) respond to cyclic AMP and cyclic GMP by increasing forward swimming speed. In association with the motile response, cyclic AMP and 8-bromo-cyclic GMP (8-Br-cyclic GMP) stimulated protein ...
Bonini, Nancy M., Nelson, David L.
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