The use of topical diclofenac in the pain management of osteoarthritis of the knee [PDF]
, 2006 Osteoarthritis (OA) is a common complaint that affects millions of people worldwide. As there is no cure for OA, drug treatment is the main form of management.
Banning, M
core +7 more sources
Diclofenac solution (Pennsaid) in the management of osteoarthritis of the knee : Patient implications [PDF]
, 2009 Topical diclofenac sodium (pennsaid) is a non-steroidal-anti- inflammatory drug that is used to manage the recurrent pain and symptoms of osteoarthritis of the knee. Pennsaid is applied topically, absorbed cutaneously and concentrates locally at the site
Banning, M
core +7 more sources
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Effects of Diclofenac, L-NAME, L-Arginine, and Pentadecapeptide BPC 157 on Gastrointestinal, Liver, and Brain Lesions, Failed Anastomosis, and Intestinal Adaptation Deterioration in 24 Hour-Short-Bowel Rats. [PDF]
PLoS ONE, 2016 Stable gastric pentadecapeptide BPC 157 was previously used to ameliorate wound healing following major surgery and counteract diclofenac toxicity. To resolve the increasing early risks following major massive small bowel resectioning surgery, diclofenac
Nermin Lojo +9 more
doaj +1 more source
Protective effects of andrographolide against diclofenac-induced gastric damage
Scientific African, 2021 The use diclofenac in pain management is limited by the development of gastric ulcers. Andrographolide is a clinically approved medicinal plant extract that has been found to possess among others, a gastro protective effect and may therefore be useful in
Augustine Tandoh +5 more
doaj +1 more source
Evaluation of Skin Penetration of Diclofenac from a Novel Topical Non Aqueous Solution: A Comparative Bioavailability Study [PDF]
Journal of Clinical and Diagnostic Research, 2015 Introduction: Different topical formulations of diclofenac have varying skin penetration profile. Recent advances in science and technology has led to the development of many new formulations of drugs for topical drug delivery. One such technological
Manish Nivsarkar +3 more
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Molecules, 2023 Diclofenac belongs to the non-steroidal anti-inflammatory drugs with analgesic, antipyretic and anti-inflammatory effects. Diclofenac administration on the skin may be associated with the appearance of side effects. The study aimed to evaluate the impact
Wioletta Dobrzeniecka +6 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Topical diclofenac: Clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries [PDF]
, 2008 Background: Diclofenac is a commonly used non-steroidal anti-inflammatory drug (NSAID) for symptom control in osteoarthritis (OA) of the knee and soft tissue injuries.
Banning, M
core +1 more source
Hepatotoxic Assessment of Tramadol-Diclofenac Use: A Study in a Rat Model
Biology, Medicine & Natural Product Chemistry, 2019 The concurrent use of tramadol and diclofenac may increase hepatotoxic risk due to their individual hepatotoxic effects. This study assessed the hepatotoxic effect of tramadol-diclofenac administration in albino rats.
Elias Adikwu, Ebinyo Clemente Nelson
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