Effects of Diclofenac, L-NAME, L-Arginine, and Pentadecapeptide BPC 157 on Gastrointestinal, Liver, and Brain Lesions, Failed Anastomosis, and Intestinal Adaptation Deterioration in 24 Hour-Short-Bowel Rats. [PDF]
PLoS ONE, 2016 Stable gastric pentadecapeptide BPC 157 was previously used to ameliorate wound healing following major surgery and counteract diclofenac toxicity. To resolve the increasing early risks following major massive small bowel resectioning surgery, diclofenac
Nermin Lojo +9 more
doaj +1 more source
Protective effects of andrographolide against diclofenac-induced gastric damage
Scientific African, 2021 The use diclofenac in pain management is limited by the development of gastric ulcers. Andrographolide is a clinically approved medicinal plant extract that has been found to possess among others, a gastro protective effect and may therefore be useful in
Augustine Tandoh +5 more
doaj +1 more source
Evaluation of Skin Penetration of Diclofenac from a Novel Topical Non Aqueous Solution: A Comparative Bioavailability Study [PDF]
Journal of Clinical and Diagnostic Research, 2015 Introduction: Different topical formulations of diclofenac have varying skin penetration profile. Recent advances in science and technology has led to the development of many new formulations of drugs for topical drug delivery. One such technological
Manish Nivsarkar +3 more
doaj +1 more source
Evaluation of Hemoadsorption Capacity of the CytoSorb Adsorber for Toxic Doses of Diclofenac and Meloxicam in Porcine Plasma. [PDF]
J Clin ApherABSTRACT The objective of this in vitro experimental was to determine the utility of hemoadsorption (HA) using the CytoSorb adsorber to remove meloxicam and diclofenac from porcine plasma. For this purpose 12 1‐L aliquots of porcine plasma, 6 units were spiked with 293 μg/mL (262–320 μg/mL) diclofenac and 6 with 42.8 μg/mL (41.4–44.7 μg/mL) meloxicam ...
Giani B +3 more
europepmc +2 more sources
Molecules, 2023 Diclofenac belongs to the non-steroidal anti-inflammatory drugs with analgesic, antipyretic and anti-inflammatory effects. Diclofenac administration on the skin may be associated with the appearance of side effects. The study aimed to evaluate the impact
Wioletta Dobrzeniecka +6 more
doaj +1 more source
Enhanced Anti-Inflammatory Effects of Nanoencapsulated Diclofenac
European Journal of Inflammation, 2013 This study was conducted to compare the anti-inflammatory efficacy of nanoencapsulated and free-form diclofenac in rat. Diclofenac-loaded liposomes were prepared using the proliposome method.
J.Z. Goh +7 more
doaj +1 more source
Hepatotoxic Assessment of Tramadol-Diclofenac Use: A Study in a Rat Model
Biology, Medicine & Natural Product Chemistry, 2019 The concurrent use of tramadol and diclofenac may increase hepatotoxic risk due to their individual hepatotoxic effects. This study assessed the hepatotoxic effect of tramadol-diclofenac administration in albino rats.
Elias Adikwu, Ebinyo Clemente Nelson
doaj +1 more source
Diclofenac topical gel in excisional wounds maintain heal quality and reduce phlogistic signals1 [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE:To investigate diclofenac topical gel as an alternative to reduce phlogistic signals and maintain quality of wound repair.METHODS:Fifteen Wistar rats were used in this study; four excisional wounds were performed on the dorsum of each animal ...
Felipe Lobato da Silva Costa +5 more
doaj +1 more source
The anti-inflammatory effect of allopurinol and diclofenac in chicks’ model [PDF]
Iraqi Journal of Veterinary Sciences, 2023 No studies have been conducted on the anti-inflammatory effect of allopurinol; eight-day old chicks are used. The aim of this paper was to study the anti-inflammatory action of allopurinol on a chemical pain model, both when administered alone or in ...
Maab A. Fadel, Khayrea A. Mustafa
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source