Targeted Protein Degradation: From Molecular Mechanisms to Emerging Therapeutic Strategies
MedComm, Volume 7, Issue 11, November 2026.Graphical overview of targeted protein degradation: mechanisms, molecular determinants, delivery strategies, and therapeutic development. This graphical abstract summarizes the major degradation pathways involved in targeted protein degradation, including the ubiquitin–proteasome system, endocytosis–lysosome pathway, and autophagy‐dependent degradation.
Huaijuan Guo +8 more
wiley +1 more source
A Straightforward Approach Towards Phosphadecalones by Microwave-Assisted Diels-Alder Reaction. [PDF]
MoleculesŁastawiecka E +2 more
europepmc +1 more source
An Investigations‐Based Undergraduate Computational Chemistry Course
Journal of Physical Organic Chemistry, Volume 39, Issue 11, November 2026.Chemistry 164 is a hands‐on undergraduate computational chemistry course at Pomona College using publicly available materials (https://tinyurl.com/PomonaChem164) and structured around literature‐based investigations of organic structure and reactivity, isotope effects, NMR parameters, and organometallic systems.
Daniel J. O'Leary
wiley +1 more source
Real-Time Visualisation of Reaction Kinetics and Dynamics: Single-Molecule Insights into the Iminium-Catalysed Diels-Alder Reaction. [PDF]
Angew Chem Int Ed EnglPark M +7 more
europepmc +1 more source
Rapid Communications in Mass Spectrometry, Volume 40, Issue 20, 30 October 2026.ABSTRACT Rationale Liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis of vitamin D3 metabolites is analytically challenging because these compounds are structurally similar, strongly matrix‐associated, and have poor ionization efficiency.
Marzieh Amirmostofian +3 more
wiley +1 more source
Investigating Cavity Quantum Electrodynamics-Enabled Endo/Exo-Selectivities in a Diels-Alder Reaction. [PDF]
J Phys Chem AWang J, Weight BM, Huo P.
europepmc +1 more source
Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics
ChemBioChem, Volume 27, Issue 20, 28 October 2026.This review highlights emerging strategies for labeling neuronal proteins, enabling visualization and quantitative analysis of their expression, localization, and dynamics. By combining genetic code expansion (GCE), metabolic labeling, and click chemistry‐based labeling, these approaches provide powerful routes to study proteins in specific cells and ...
Neil Taylor +2 more
wiley +1 more source
Supramolecular Mechanophore Additives Enable Mechanochromic Hydrogels
Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.A supramolecular loop‐forming mechanophore featuring a quencher and an emitter is incorporated as a water‐soluble macromolecular additive into hydrogels. In the stress‐free state, intramolecular charge‐transfer interactions fold the loop and quench fluorescence.
Iulia Scarlat +2 more
wiley +2 more sources
Synthesis of benzoquinone compounds by a microdroplet-accelerated retro-Diels-Alder reaction. [PDF]
Chem SciMalkoti N, Meng Y, Zare RN, Gnanamani E.
europepmc +1 more source
Sustainable Routes Toward Amino Acid‐Based Surfactants: Borrowing Hydrogen Catalysis and Beyond
ChemSusChem, Volume 19, Issue 20, 28 October 2026.This perspective examines how amino acid‐based surfactants become more sustainable only when molecular architecture is matched to an appropriate synthetic disconnection. Borrowing Hydrogen catalysis provides a central route to N‐alkylated derivatives, while enzymatic, biosynthetic, and renewable‐platform strategies complement it.
Maximilian Fellert, Ben L. Feringa
wiley +1 more source