A Unified Approach for the Synthesis of Conformationally Locked and sp2‐sp3 Fused Hybrids
This study presents a systematic platform to build rigid sp2–sp3 hybrids via benzyne cycloadditions. Arene‑fused bicyclic oxa‐, aza‐, and carbocycles are converted into medicinally relevant amino acids and applied to Enalapril analogues synthesis. The hybrids combine aromatic interactions with 3D rigidity, tuning lipophilicity, pKa, and solubility ...
Ervis Saraci +8 more
wiley +1 more source
Flavin Catalysts in Organic Synthesis
Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley +2 more sources
Analysis of the Reactivity of Z-2-Ar-1-EWG-1-Nitroethene Molecular Segment in the Hetero Diels-Alder Reaction: Experimental and MEDT Quantum Chemical Study. [PDF]
Woliński P +4 more
europepmc +1 more source
The Expanding Role of Diazirines in Synthetic Methodology
Beyond their established role in photoaffinity labeling, diazirines have emerged as versatile reagents in synthetic chemistry. This review highlights their dual reactivity as carbene and nitrogen‐transfer precursors, showcasing mechanistic insights and diverse applications in cyclopropanations, cycloadditions, skeletal editing, amination, heterocycle ...
Viktor Savic +3 more
wiley +1 more source
Self-Healing and Recyclable Polyurethane/Nanocellulose Elastomer Based on the Diels-Alder Reaction. [PDF]
Yang T +9 more
europepmc +1 more source
DFT Investigation of the Stereoselectivity of the Lewis-Acid-Catalyzed Diels-Alder Reaction between 2,5-Dimethylfuran and Acrolein. [PDF]
Chellegui M +3 more
europepmc +1 more source
Towards Greener Synthesis of Substituted 3-Aminophthalates Starting from 2<i>H</i>-Pyran-2-ones via Diels-Alder Reaction of Acetylenedicarboxylates. [PDF]
Fendre D, Lukšič M, Kranjc K.
europepmc +1 more source
Self-Healing Thermal-Reversible Low-Temperature Polyurethane Powder Coating Based on Diels-Alder Reaction. [PDF]
Pojnar K +6 more
europepmc +1 more source
Synthesis of the Spirocyclic Imine Fragment of Portimines Using a γ-Hydroxymethyl-α,β-butenolide Dienophile in a Diastereoselective Diels-Alder Reaction. [PDF]
Kuang Z, Ding XB, Li FF, Brimble MA.
europepmc +1 more source
An MEDT Study of the Reaction Mechanism and Selectivity of the Hetero-Diels-Alder Reaction Between 3-Methylene-2,4-Chromandione and Methyl Vinyl Ether. [PDF]
Bouhaoui A +3 more
europepmc +1 more source

