Results 71 to 80 of about 2,016,526 (312)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Tracking Ungulate Diet: Comparing Observational and DNA Metabarcoding Tools

Environmental DNA
Large mammalian herbivores (LMH) are abundant in grazing ecosystems and play a pivotal role in shaping vegetation characteristics. However, accurately determining their diets through traditional methods, such as direct observations, remains challenging ...
Forman Roi, Berman Tali Sarah, Zhong Zhiwei, Dines Monica, Wang Deli, Inbar Moshe   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Sex‐specific diet differences in harbor seals (Phoca vitulina) via spatial assortment

Ecology and Evolution
The lack of recovery of Chinook salmon (Oncorhynchus tshawytscha) in the Pacific Northwest has been blamed in part on predation by pinnipeds, particularly the harbor seal (Phoca vitulina).
Holland C. Conwell, Zoë K. Lewis, Austen Thomas, Alejandro Acevedo‐Gutiérrez, Dietmar Schwarz   +4 more
doaj   +1 more source

Validation and Modification of a Short Diet Screener “Diet Analysis”

Hrvatski časopis za prehrambenu tehnologiju, biotehnologiju i nutricionizam
Short questionnaires are increasingly used tools for quickly assessing dietary quality. In this study, a new questionnaire called “diet analysis” was validated and modified. The questionnaire consisting of 18 questions divided into 3 categories (completion time: 3-5 minutes). The objective was to compare the relative validity of this questionnaire with
Bubanko, Mia, Gajdoš Kljusurić, Jasenka, Šatalić, Zvonimir, Stojnić, Bojan   +3 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The contribution of diet and genotype to iron status in women:a classical twin study [PDF]

, 2013
This is the first published report examining the combined effect of diet and genotype on body iron content using a classical twin study design. The aim of this study was to determine the relative contribution of genetic and environmental factors in ...
Alexander J. Macgregor, AM Minihane, Ana M. Valdes, Ana Paula Arez, Anna A. Wawer, B Benyamin, B Lonnerdal, B Teucher, BA Thompson, CE McLaren, D Gaitán, G Rybo, Geoffrey R. Guile, Jane Skinner, JB Whitfield, JB Whitfield, JD Cook, JN Feder, K Oexle, L Almasy, L Hallberg, LJ Harvey, OM Visscher, R Hurrell, Rachel Hurst, SA Bingham, SJ Thorpe, Susan J. Fairweather-Tait   +27 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cost Benefit Analysis of Popular Diets

, 2023
The increase in obesity in recent years has led to the creation of numerous diets claiming to induce weight loss and improve overall health. While all diets claim to be the best, it is difficult to determine which diet provides the most utility given the costs of participation. These diets have varying scientific evidence to support the claims made and
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source