Results 81 to 90 of about 1,374,562 (233)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Comparison of sleep quality, diet quality, and weight change between COVID‐19‐recovered patients and healthy controls: A matched case‐control study

Health Science Reports
Background and Aim Literature suggests that individuals who have recovered from COVID‐19 may experience post‐COVID conditions, including sleep problems and alterations in smell or taste.
Farha Ainin Sofia Muzaffar, Seok Tyug Tan   +1 more
doaj   +1 more source

Transcriptome analysis of porcine M. semimembranosus divergent in intramuscular fat as a consequence of dietary protein restriction [PDF]

, 2013
peer-reviewedBackground: Intramuscular fat (IMF) content is positively correlated with aspects of pork palatability, including flavour, juiciness and overall acceptability.
Aslan, Ozlem, Hamill, Ruth M, McBryan, Jean, Morris, Dermot G., Mullen, Anne Maria, O'Doherty, John V., Sweeney, Torres   +6 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Effect of grass–clover forage and whole-wheat feeding on the sensory quality of eggs [PDF]

, 2010
BACKGROUND: A sensory panel evaluated the sensory profile of eggs from hens from three experimental systems: (1) an indoor system × normal layer diet (InL), (2) a grass–clover forage system × normal layer diet (GrL), and (3) a grass–clover forage system
Allesen-Holm, B.H., Hammershøj, M., Horsted, K.   +2 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Comparing Predictors of Diet Quality in Canada Over Time Under Consideration of Altering Food Guides [PDF]

Latest data on the diet of Canadians from the Canadian Community Health Survey reveals that the diet quality of Canadians needs improvement. Within this paper predictors of diet quality in Canada are identified based on two cross-sectional data sets from
Drescher, Larissa S., Goddard, Ellen W.
core   +1 more source

Abundance, condition, and diet of juvenile Pacific ocean perch (Sebastes alutus) in the Aleutian Islands [PDF]

, 2009
T he relative value of pelagic habitat for three size classes of juvenile Pacific ocean perch (Sebastes alutus) was investigated by comparing their abundance and condition in two areas of the Aleutian Islands. Diet, zooplankton biomass, and water column
Boldt, Jennifer L., Rooper, Christopher N.   +1 more
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

The associations of diet quality and cardiometabolic indicators in children and the mediation role of cardiorespiratory fitness

Frontiers in Nutrition
BackgroundCardiometabolic health in children has become a growing global concern due to its long-term association with chronic diseases such as cardiovascular disease and type 2 diabetes.
Ping-Ping Zhang, Ping-Ping Zhang, Gao-Feng Lin, Jia-Ying Gu, Jia-Ying Gu, Bi-Lian Wang, Jie Zhang, Jie Zhang, Ye Zhou, Miao Xu, Hui Wang, Li Li   +11 more
doaj   +1 more source