Results 161 to 170 of about 3,451,750 (306)

Ketogenic diet therapy for epilepsy in Australia: insights from the Pharmaceutical Benefits Scheme. [PDF]

Intern Med J
Kaul N, King L, Chen S, Kwan P, O'Brien TJ.   +4 more
europepmc   +1 more source

Development of a Practical Guide to Implement and Monitor Diet Therapy for Eosinophilic Esophagitis. [PDF]

Clin Gastroenterol Hepatol, 2023
Chang JW, Kliewer K, Haller E, Lynett A, Doerfler B, Katzka DA, Peterson KA, Dellon ES, Gonsalves N, Consortium of Eosinophilic Gastrointestinal Disease Researchers.   +9 more
europepmc   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity. [PDF]

Nutrients
Deseatnicova E, Covaliov E, Deseatnicova O, Siminiuc R, Rezus E, Groppa L.   +5 more
europepmc   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

A randomized controlled trial of a multimodality digital health intervention to aid the delivery of the modified ketogenic diet therapy for epilepsy: The Keto eCoach trial protocol. [PDF]

Epilepsia Open
Kaul N, Vivash L, Chen S, King L, Johns H, Churilov L, Chen Z, Nicolo JP, Heaven D, Meredith E, Ervine R, Todd L, Zappa B, Ademi Z, Geethadevi GM, Erlichster M, Skafidas E, O'Brien TJ, Kwan P.   +18 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Ketogenic diet therapy for children with super-refractory status epilepticus in intensive care: International clinical practice recommendations. [PDF]

Epilepsia Open
Blackford R, Whiteley VJ, Hardy I, Armeno M, Bollard T, Cross JH, Eltze C, George S, Howard C, Nijstad AL, Talzzia E, Paget C, Ray S, Simpson Z, Song-Pozderac E, Szmurlo A, Tan-Smith C, Vanatta L, van der Louw E, Schoeler NE, Ketogenic Dietitians Research Network.   +20 more
europepmc   +1 more source

The Crucial Role of Diet Therapy and Selenium on the Evolution of Clinical and Paraclinical Parameters in Patients with Metabolic Syndrome. [PDF]

J Nutr Metab, 2023
Danciu AM, Ghitea TC, Bungau AF, Vesa CM.   +3 more
europepmc   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source