Results 51 to 60 of about 358,559 (266)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Unveiling sex-specific cardiometabolic and adiposity risk profiles for precision prevention

European Journal of Medical Research
Introduction Cardiometabolic diseases (CMDs) are the leading global cause of mortality, driven by interrelated metabolic and cardiovascular factors. Sex differences significantly shape risk.
Gianvincenzo Zuccotti, Paolo Osvaldo Agnelli, Lucia Labati, Erika Cordaro, Davide Braghieri, Paolo Fiorina, Simona Bertoli, Cesare Celeste Federico Berra, Marina Croci, Maria Elena Malighetti, Fabrizio Losurdo, Andrea Foppiani, Loredana Bucciarelli, Alberto Battezzati, Marco Xodo, Sergio De Pasquale, Valeria Calcaterra   +16 more
doaj   +1 more source

Evaluation of the Scientific Quality and Usability of Digital Dietary Assessment Tools

Dietetics
The importance of digital tools for dietary assessment has increased in recent years, both commercially and scientifically. In the field of nutrition research, the digitization of dietary assessment methods presents many opportunities and risks.
Vanessa Böse, Marius Frenser, Melanie Schumacher, Tobias Fischer   +3 more
doaj   +1 more source

The Validity and Reproducibility of Dietary Non-enzymatic Antioxidant Capacity Estimated by Self-administered Food Frequency Questionnaires

Journal of Epidemiology, 2018
Background: High dietary non-enzymatic antioxidant capacity (NEAC) has been inversely related to the incidence of degenerative diseases. However, few studies have investigated the validity and reproducibility of dietary NEAC estimated from a food ...
Ikuko Kashino, Mauro Serafini, Junko Ishihara, Tetsuya Mizoue, Ayaka Sunami, Koutatsu Maruyama, Norie Sawada, Manami Inoue, Akiko Nanri, Kayo Kurotani, Shamima Akter, Motoki Iwasaki, Shoichiro Tsugane   +12 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Dietary Intake of Infant and Young Children and Assessment of Dietary Adequacy Indicators in a Pastoral Setting, Southern Ethiopia

Nutrition and Dietary Supplements, 2020
Bekele Megersa Faculty of Veterinary Medicine, College of Computational and Natural Science, Hawassa University, Hawassa, EthiopiaCorrespondence: Bekele MegersaFaculty of Veterinary Medicine, College of Computational and Natural Science, Hawassa ...
Megersa B
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Dietary assessment methods: dietary records.

Nutricion hospitalaria, 2016
Dietary records or food diaries can be highlighted among dietary assessment methods of the current diet for their interest and validity. It is a prospective, open-ended survey method collecting data about the foods and beverages consumed over a previously specified period of time.
Rosa M, Ortega, Carmen, Pérez-Rodrigo, Ana M, López-Sobaler   +2 more
openaire   +1 more source