Results 71 to 80 of about 596,234 (310)

Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice [PDF]

, 2012
<p>Background: Dietary restriction (DR) extends lifespan and induces beneficial metabolic effects in many animals. What is far less clear is whether animals retain a metabolic memory to previous DR exposure, that is, can early-life DR preserve ...
A Ceriello, A Dubey, A Nakamura, A Taguchi, BJ Merry, BJ Merry, BP Yu, BS Hass, C Hambly, C Messier, C Selman, C Selman, CK Lee, CK Lee, DP Argentino, EP Weiss, F Capstick, H Maeda, J Cantley, J Jacobson, JD Mulligan, JF Clinthorne, JM Dhahbi, JM Dhahbi, JR Mitchell, JR Speakman, L Fontana, LK Heilbronn, LM Redman, MJ Forster, MJ Forster, R Weindruch, R Weindruch, RJ Colman, RM Anson, S Goto, S Hempenstall, S Keipert, S Park, S Rezzi, SK Barnes, SL Johnston, SS Jessani, SX Cao, TM Wallace, W Mair, X Li   +46 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Statement on non‐dietary exposure on diquat [PDF]

EFSA Journal, 2018
In response to an application to renew the approval of the active substance diquat, EFSA completed an assessment in 2015 under the second group of the renewal programme (Regulation (EC) No 1141/2010). During the subsequent consultation on the EFSA conclusion between the applicants and the European Commission, the need to reassess non-dietary exposure ...
openaire   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Reproductive and Developmental Effects of Sex-Specific Chronic Exposure to Dietary Arsenic in Zebrafish (Danio rerio)

Toxics
The present study investigated the reproductive and developmental effects of sex-specific chronic exposure to dietary arsenic in zebrafish. Adult zebrafish (Danio rerio) were exposed to environmentally realistic doses of arsenic via diet [0 (control; no ...
Mahesh Rachamalla, Arash Salahinejad, Vladimir Kodzhahinchev, Som Niyogi   +3 more
doaj   +1 more source

Efficacy of interventions that use apps to improve diet, physical activity and sedentary behaviour : a systematic review [PDF]

, 2016
Background: Health and fitness applications (apps) have gained popularity in interventions to improve diet, physical activity and sedentary behaviours but their efficacy is unclear.
Alley, Stephanie, Bray, Nicola A, Duncan, Mitch J, Schoeppe, Stephanie, Van Lippevelde, Wendy, Vandelanotte, Corneel, Williams, Susan L   +6 more
core   +4 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Dietary Acrylamide Exposure and Risk of Site-Specific Cancer: A Systematic Review and Dose-Response Meta-Analysis of Epidemiological Studies

Frontiers in Nutrition, 2022
Diet is a main source of acrylamide exposure to humans. Existing observational data on the relationship between dietary exposure to acrylamide and risk of cancer are inconsistent.
Tommaso Filippini, Thorhallur I. Halldorsson, Thorhallur I. Halldorsson, Carolina Capitão, Carolina Capitão, Raquel Martins, Raquel Martins, Konstantinos Giannakou, Konstantinos Giannakou, Janneke Hogervorst, Marco Vinceti, Marco Vinceti, Agneta Åkesson, Karin Leander, Andromachi Katsonouri, Osvaldo Santos, Osvaldo Santos, Osvaldo Santos, Ana Virgolino, Ana Virgolino, Federica Laguzzi   +20 more
doaj   +1 more source

Maternal obesity has little effect on the immediate offspring but impacts on the next generation [PDF]

, 2013
Maternal obesity during pregnancy has been linked to an increased risk of obesity and cardiometabolic disease in the offspring, a phenomenon attributed to developmental programming. Programming effects may be transmissible across generations through both
Dakin, Rachel S., Drake, Amanda J., Hadoke, Patrick W. F., King, Vicky, Liu, Lincoln, Norman, Jane E., Seckl, Jonathan R., Walker, Brian R.   +7 more
core   +1 more source

Exposure apportionment: Ranking food items by their contribution to dietary exposure [PDF]

Journal of Exposure Science & Environmental Epidemiology, 2002
This paper identifies and ranks food items by estimating their contribution to the dietary exposure of the US population and 19 subpopulation groups. Contributions to dietary exposures to arsenic, cadmium, chromium, lead, nickel, benzene, chlorpyrifos, and diazinon are estimated using either the Dietary Exposure Potential Model (DEPM) approach, the ...
D J, Moschandreas, S, Karuchit, M R, Berry, M K, O'Rourke, D, Lo, M D, Lebowitz, G, Robertson   +6 more
openaire   +2 more sources