Results 71 to 80 of about 2,474,608 (304)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Joint venture on the further development of chemical exposure assessment by use of probabilistic modelling

EFSA Journal, 2019
Exposure assessment is a fundamental component of the risk assessment process and has a significant contribution to the overall uncertainty of the risk estimates. The aim of the present project, implemented within the framework of the EU‐FORA Fellowship,
Austrian Agency for Health and Food Safety (AGES), Christina Vlachou, Daniela Hofstädter   +2 more
doaj   +1 more source

The 2019 European Union report on pesticide residues in food

EFSA Journal, 2021
Under European Union legislation (Article 32, Regulation (EC) No 396/2005), the EFSA provides an annual report which examines pesticide residue levels in foods on the European market.
European Food Safety Authority (EFSA), Luis Carrasco Cabrera, Paula Medina Pastor   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Occurrence and Exposure Assessment of Lipophilic Shellfish Toxins in the Zhejiang Province, China

Marine Drugs
Although lipophilic shellfish toxins (LSTs) pose a significant threat to the health of seafood consumers, their systematic investigation and risk assessment remain scarce.
Qin Weng, Ronghua Zhang, Pinggu Wu, Jiang Chen, Xiaodong Pan, Chenyang Zheng, Dong Zhao, Jikai Wang, Hexiang Zhang, Xiaojuan Qi, Junde Han, Zijie Lu, Biao Zhou   +12 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Early exposure to toxic metals has a limited effect on blood pressure or kidney function in later childhood, rural Bangladesh. [PDF]

, 2012
BACKGROUND: Chronic exposure to toxic metals such as arsenic and cadmium has been implicated in the development of kidney and cardiovascular diseases but few studies have directly measured exposure during inutero and early child development.
Fulford, Anthony JC, Persson, Lars-Ake, Vahter, Marie, Arifeen, SE, Kippler, M,, Wagatsuma, Yukiko, Hawkesworth, Sophie, Persson, L-A, Vahter, M,, Hawkesworth, S, Fulford, AJC, Kippler, Maria, Moore, SE, Moore, Sophie E, Fulford, Anthony J. C., Wagatsuma, Y, Moore, Sophie E., Arifeen, Shams E, Arifeen, Shams E., Persson, Lars-Ake,   +19 more
core   +1 more source

Development and validation of a dietary assessment tool to determine dietary intake of people living in oesophageal cancer risk areas in the rural Eastern Cape of South Africa [PDF]

, 2011
Rural areas in the Eastern Cape (EC) Province of South Africa have a high incidence of oesophageal cancer (OC). Amongst the known risk factors associated with the cancer is fumonisin exposure (a mycotoxin growing on maize), poor dietary habits and ...
Lombard, Martani Johanni
core   +1 more source

Partitioning of Dietary Metal Intake—A Metal Dietary Exposure Screening Tool [PDF]

Risk Analysis, 2014
Detection of heavy metals at trace or higher levels in foods and food ingredients is not unexpected given the widespread unavoidable presence of several metals in nature, coupled with advancement in analytical methods and lowering limits of detection.
Nga L, Tran, Leila M, Barraj, Carolyn, Scrafford, Xiaoyu, Bi, Terry, Troxell   +4 more
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source