Results 241 to 250 of about 8,470,846 (303)

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

open access: yesAdvanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun   +15 more
wiley   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

open access: yesAdvanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao   +10 more
wiley   +1 more source

Global burden of TBL cancer in older adults: the role of dietary factors (1990-2021). [PDF]

open access: yesBMC Public Health
Zhang W   +7 more
europepmc   +1 more source
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Dietary Factors

2010
Besides tobacco and alcohol – the two major recognized risk factors for oral and pharyngeal cancer in most populations – diet and nutrition have been suggested to play an important role in the etiology of these neoplasms [1– 4] . The epidemiological evidence on diet and oral and pharyngeal cancer comes mainly from case–control studies, and the few ...
E. Lucenteforte   +3 more
openaire   +4 more sources

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