Results 261 to 270 of about 164,007 (344)

The Molecular Basis of Amino Acids Sensing

Advanced Science, EarlyView.
Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang, Xiao Tan, Jiali Jin, Ping Wang   +3 more
wiley   +1 more source

Influence of Dietary Fat on the Fatty Acid Composition in Depot Fat

, 1967
Yasumasa Majima, Chieko Kurata
openalex   +2 more sources

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

Advanced Science, EarlyView.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen   +18 more
wiley   +1 more source

Dietary fats suppress the peritoneal seeding of colorectal cancer cells through the TLR4/Cxcl10 axis in adipose tissue macrophages. [PDF]

Signal Transduct Target Ther, 2020
Xiang W, Shi R, Zhang D, Kang X, Zhang L, Yuan J, Zhang X, Miao H.   +7 more
europepmc   +1 more source

Dietary Fat and Its Relation to Heart Attacks and Strokes

, 1961
Irvine H. Page, Edgar V. Allen, Francis L. Chamberlain, Ancel Keys, Jeremiah Stamler, Fredrick J. Stare   +5 more
openalex   +1 more source

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

The effect of dietary essential fatty acids upon composition of polyunsaturated fatty acids in depot fat and erythrocytes of the rat

, 1963
Hans Mohrhauer, Ralph T. Holman
openalex   +1 more source

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
This study identifies a class of amino acid‐sensing neurons, APCCRH neurons, which regulate BAT thermogenesis. Leucine deficiency alters intrinsic excitability through GCN2 signaling pathway, activating APCCRH neurons, which in turn regulate BAT thermogenesis via projections to the lateral hypothalamus.
Peixiang Luo, Kexin Tong, Yeting Gan, Min Tang, Yuguo Niu, Kan Liu, Shihong Ni, Shangming Wu, Xiaoxue Jiang, Haizhou Jiang, Fei Xiao, Shanghai Chen, Wei Lv, Xiaoying Li, Feixiang Yuan, Feifan Guo   +15 more
wiley   +1 more source

3'quant mRNA-Seq of Porcine Liver Reveals Alterations in UPR, Acute Phase Response, and Cholesterol and Bile Acid Metabolism in Response to Different Dietary Fats. [PDF]

Genes (Basel), 2020
Oczkowicz M, Szmatoła T, Świątkiewicz M, Koseniuk A, Smołucha G, Witarski W, Wierzbicka A.   +6 more
europepmc   +1 more source

Fatty Acid Composition of Milk. I. Effect of Roughage and Dietary Fat

, 1962
William H. Brown, J.W. Stull, G.H. Stott
openalex   +1 more source