Results 81 to 90 of about 76,974 (244)
m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis
Advanced Science, EarlyView.This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang +26 more
wiley +1 more source
Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling
Cell ReportsSummary: Dietary fat composition has changed substantially during the obesity epidemic. As adipocyte hyperplasia is a major mechanism of adipose expansion, we aim to ascertain how dietary fats affect adipogenesis during obesity.
Allison Wing +15 more
doaj +1 more source
Advanced Science, EarlyView.An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang +14 more
wiley +1 more source
Advanced Science, EarlyView.This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha +5 more
wiley +1 more source
Dietary Fats and Cognitive Status in Italian Middle-Old Adults. [PDF]
Nutrients, 2023 Currenti W +8 more
europepmc +1 more source
Plasma metabolic signatures of dietary fats and risk of prediabetes
Food Science and Human WellnessThe metabolic response to dietary fat intake and its association with prediabetes are unclear. We aimed to identify the plasma metabolite profiles related to dietary fats and test if they are associated with prediabetes risk.
Pan Zhuang +9 more
doaj +1 more source
Research progress on application of oil in laying poultry industry
Siliao yanjiu, 2023 Oils and fats are an important source of energy for animals and a good carrier of fat-soluble nutrients, which can participate in various life activities of the body and are widely used in animal production.
DING Yong-wang, JIN Er-hui, CHEN Wei
doaj
FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis
Advanced Science, EarlyView.ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li +16 more
wiley +1 more source
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis
Advanced Science, EarlyView.Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao +28 more
wiley +1 more source
Human‐Centered Innovation: Precision Nutrition and the Future of Food
Advanced Science, EarlyView.ABSTRACT Nutritional science is moving beyond one‐size‐fits‐all recommendations toward more precise and personalized approaches, yet its implementation pathway remains unclear. This paper proposes a human‐centered precision nutrition framework that highlights the central roles of artificial intelligence (AI), food innovation, and human agency.
Shanshan Zhang +3 more
wiley +1 more source