Results 131 to 140 of about 5,815,839 (281)

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Association between dietary inflammatory index, empirical dietary inflammatory patterns, dietary and lifestyle inflammation scores, and polycystic ovary syndrome: a case-control study

BMC Endocrine Disorders
Background Polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder affecting women of reproductive age. Chronic low-grade inflammation is implicated in its pathogenesis, with diet and lifestyle playing pivotal roles.
Fatemeh Vaziri Esfarjani, Parvin Dorfeshan, Anahita Mansouri, Farnush Bakhshimoghaddam, Roshan Nikbakht, Shahla Vaziri Esfarjani, Hadis Varaee   +6 more
doaj   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Evaluation of Healthy Eating Index and Children's Diet Inflammatory Index according to asthma severity group

BMC Pediatrics
Background Diet may contribute to better asthma control in children by impacting the immune and inflammatory pathophysiology. Therefore, this study aimed to investigate differences in nutrient intake, Children’s Dietary Inflammatory Index (C-DII), and ...
Nevra Koç, Nursena Ersoy, Hülya Yardimci, İlknur Külhaş Çelik, Ersoy Civelek   +4 more
doaj   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Dietary inflammatory index during pregnancy and its relationship with gyrification and IQ in young adult offspring

Dietary inflammatory index during pregnancy and its relationship with gyrification and IQ in young adult ...
L Andryskova (21247613), L Holland (13686343), R Marecek (21247610), K Mareckova (21247607), M Brazdil (21247616), Samantha Dawson (13066098), YS Nikolova (21247619)   +6 more
core  

Diet quality, dietary inflammatory index and body composition as predictors of N-acetylcysteine and mitochondrial agents efficacy in bipolar disorder

, 2019
Diet quality, dietary inflammatory index and body composition as predictors of N-acetylcysteine and mitochondrial agents efficacy in bipolar ...
Olivia Dean (13088112), Seetal Dodd (13093767), J Sarris (9773810), C Voigt (13496188), GS Malhi (9885515), M Hopwood (13329972), K Faye-Chauhan (13380318), Alyna Turner (13057884), Michael Berk (13060851), Y Kim (3108876), SR Dash (14543174), Wolf Marx (13100121), C Ng (9850451), SM Cotton (12746624), Melanie Ashton (13059330), M Mohebi (13565335), J Hebert (13449330), N Shivappa (12497239), Felice Jacka (13069962)   +18 more
core  

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Metal exposures and their interactions with the dietary inflammatory index on inflammatory biomarkers in Mexican adolescents

Environmental Epidemiology
Background: Heavy metals, like lead, arsenic, and cadmium, are linked to increased inflammation even in early life; however, anti-inflammatory diets may offset these effects. Methods: We evaluated associations between heavy metals and ...
Yanelli Rodríguez-Carmona, Ana Baylin, Peter X. K. Song, Edward Ruiz-Narvaez, Cindy W. Leung, James R. Hebert, Nitin Shivappa, Michael D. Wirth, Alejandra Cantoral, John D. Meeker, Niladri Basu, Martha María Tellez-Rojo, Karen E. Peterson, Sung Kyun Park   +13 more
openaire   +2 more sources

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source