Results 111 to 120 of about 2,469,952 (262)

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source

Dietary interventions for modulating the gut microbiome in PCOS management

Frontiers in Endocrinology
BackgroundPolycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder affecting about 10% of reproductive-age women. It is defined by insulin resistance, androgen excess, and chronic inflammation, which drive both reproductive and metabolic ...
Ekta Patel
doaj   +1 more source

A Blend of Phellodendron and Crape Myrtle Improves Glucose Tolerance in Exercise-Trained Men

Nutrition and Metabolic Insights, 2011
Background The purpose of this study was to investigate the acute effects of a nutritional supplement containing a proprietary blend of Phellodendron and Crape Myrtle on serum glucose and insulin in response to a modified oral glucose tolerance test ...
Robert E. Canale, Tyler M. Farney, Cameron G. McCarthy, Richard J. Bloomer   +3 more
doaj   +1 more source

Management and efficacy of intensified insulin therapy starting in outpatients [PDF]

, 1989
Diabetic patients under multiple injection insulin therapy (i.e., intensified insulin therapy, IIT) usually start this treatment during hospitalization. We report here on the logistics, efficacy, and safety of IIT, started in outpatients.
Winkelmann, W., W. Hummerich, M. Steffen, B. Allolio, Allolio, B., G. Ollenschläger, W. Winkelmann, M. Reincke, Hummerich, W., Steffen, M., Ollenschläger, G., Reincke, Martin   +11 more
core   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

The association of dietary insulin load and index with the risk of cancer and cancer mortality: a systematic review and meta-analysis. [PDF]

J Diabetes Metab Disord, 2022
Teymoori F, Mokhtari E, Bahrami A, Farhadnejad H, Azadi M, Nazarzadeh M, Vafa M.   +6 more
europepmc   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Influence of dietary insulin scores on survival in colorectal cancer patients

, 2017
BACKGROUND: Although hyperinsulinemia is hypothesised to be involved in colorectal carcinogenesis, it remains unclear whether a diet inducing an elevated insulin response influences colorectal cancer (CRC) survival.
Sato, K., Chen Yuan, Edward L Giovannucci, Yuan, C., Mingyang Song, Meir J Stampfer, Ng, K., Jeffrey A Meyerhardt, Walter C Willett, Bao, Y., Nimptsch, K., Wu, K., Brand-Miller, J.C., Kimmie Ng, Stampfer, M.J., Ying Bao, Willett, W.C., Song, M., Morales-Oyarvide, V., Jennie C Brand-Miller, Brian M Wolpin, Andrew T Chan, Kana Wu, Katharina Nimptsch, Charles S Fuchs, Meyerhardt, J.A., Kaori Sato, Keum, N., Vicente Morales-Oyarvide, NaNa Keum, Wolpin, B.M., Chan, A.T., Fuchs, C.S., Emilie S Zoltick, Giovannucci, E.L., Zoltick, E.S.   +35 more
core   +1 more source

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source