Results 61 to 70 of about 539,261 (308)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Relationship Between Dietary Patterns and Carotid Atherosclerosis Among People Aged 50 Years or Older: A Population-Based Study in China

Frontiers in Nutrition, 2021
Background: The relationship between dietary patterns and atherosclerosis is inconclusive. Usually, diets vary greatly among different regions due to cultural differences and lifestyles. Few studies to date based on a Chinese population have investigated
Yunyun Liu, Xuena Wang, Qing Zhang, Ge Meng, Ge Meng, Li Liu, Hongmei Wu, Yeqing Gu, Shunming Zhang, Yawen Wang, Tingjing Zhang, Magdalena J. Górska, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Liping Tan, Kaijun Niu, Kaijun Niu, Kaijun Niu, Kaijun Niu, Kaijun Niu   +22 more
doaj   +1 more source

Lifestyle Profile of Elderly Living with Non-communicable Disease in Bangkok and Surabaya [PDF]

, 2019
Lifestyle is one of the underlying risk factor of non-communicable disease (NCD). Dietary habit and exercise pattern are two indicators of lifestyle. Elderly are prone to NCD due to increased age which being independent risk factor.
Artsanthia, J. (Jintana), Sari, N. P. (Ni)   +1 more
core  

Relation between breast cancer and high glycemic index or glycemic load : a meta-analysis of prospective cohort studies [PDF]

, 2015
Breast cancer is the commonest form of cancer in women worldwide. It has been suggested that chronic hyperinsulinemia associated with insulin resistance plays a role in breast cancer etiology.
Autier, Philippe, Boniol, Mathieu, Boyle, Peter, Koechlin, Alice, Mullie, Patrick   +4 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Association between external eating and dietary patterns among middle school students in Chongqing, China

Frontiers in Nutrition
BackgroundThe dietary pattern, serving as a comprehensive indicator of the nutritional intake of middle school students, plays a crucial role in guiding their health.
Yingjiao Deng, Yingjiao Deng, Yingjiao Deng, Yingjiao Deng, Lingxi Zhao, Linlu Guo, Linlu Guo, Linlu Guo, Linlu Guo, Yu Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Yuanyuan Lan, Yuanyuan Lan, Yuanyuan Lan, Yuanyuan Lan, Youtao Mou, Youtao Mou, Youtao Mou, Youtao Mou, Wenhua Ran, Ling Liu, Zumin Shi, Yong Zhao, Yong Zhao, Yong Zhao, Yong Zhao, Yong Zhao   +28 more
doaj   +1 more source

Dietary patterns and socioeconomic position [PDF]

European Journal of Clinical Nutrition, 2010
To test a socioeconomic hypothesis on three dietary patterns and to describe the relation between three commonly used methods to determine dietary patterns, namely Healthy Eating Index, Mediterranean Diet Score and principal component analysis.Cross-sectional design in 1852 military men.
Mullie, Patrick, Clarys, Peter, Hulens, M., Vansant, G.   +3 more
openaire   +3 more sources

Healthy Aging and Dietary Patterns

Nutrients, 2022
A number of factors contribute to the complex process of aging, which finally define whether someone will or not develop age-associated chronic diseases in late life. These determinants comprise genetic susceptibility as well as various behavioral, environmental, and dietary factors, all of which have been shown to influence specific pathways ...
Dominguez, L. J., Veronese, N., Baiamonte, E., Guarrera, M., Parisi, A., Ruffolo, C., Tagliaferri, F., Barbagallo, M.   +7 more
openaire   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source