Results 151 to 160 of about 265,421 (313)

Bionic Microneedle Patch Inspired by Drosophila Tarsal Paws Boosts Healing in Bacterial Infectious Stomatitis

open access: yesAdvanced Science, EarlyView.
Microneedle suction cup patches, prepared using bionic Drosophila tarsal claws, can effectively treat bacterial infectious stomatitis by rapidly and efficiently leveraging multiple effects, including antibacterial and anti‐inflammatory properties, promotion of vasodilation, and active mechanical contraction of the wound.
Jiaqi Qin   +6 more
wiley   +1 more source

Liver proteomics identifies a disconnect between proteins associated with de novo lipogenesis and triglyceride storage

open access: yesJournal of Lipid Research
De novo lipogenesis (DNL) has been implicated in the development and progression of liver steatosis. Hepatic DNL is strongly influenced by dietary macronutrient composition with diets high in carbohydrate increasing DNL while diets high in fat decrease ...
Lewin Small   +7 more
doaj  

Hosts and Commensal Bacteria Synergistically Antagonize Opportunistic Pathogens at the Single‐Cell Resolution

open access: yesAdvanced Science, EarlyView.
In the tripartite‐species model, Drosophila larvae stimulate lactate production through excreting digestion enzymes. S. marcescens population senses a cue of lactate and tends to diverge into virulent and reduced virulence subclusters with remarkable heterogeneity to metabolize carbon metabolism and counter colonization resistance, giving a fitness ...
Sheng Zhang   +10 more
wiley   +1 more source

Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis

open access: yesAdvanced Science, EarlyView.
Weight cycling in Humans is suspected to dysregulate eating behavior. Mice submitted to body weight cycling by alternating western‐type and regular chow diets display increased hedonic appetite when exposed to a palatable diet, reminiscent of binge‐eating episodes.
Mélanie Fouesnard   +13 more
wiley   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang   +15 more
wiley   +1 more source

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