Results 201 to 210 of about 1,087,542 (336)

Pre-pregnancy and early pregnancy dietary patterns and gestational diabetes risk among Miao women in China. [PDF]

Front Nutr
Zhang S, Ni X, Qiao T, Zhao D, Shen L, Liang Y.   +5 more
europepmc   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Macronutrient quality and colorectal cancer outcomes: evidence from the PLCO screening trial. [PDF]

Front Nutr
Feng D, Xiang L, Wen K, Xiao Y, Gu H, Peng L, Luo Y, Wang Y, Liu D, Zhou Z, Liu Q.   +10 more
europepmc   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Associations of dietary biotin intake on anxiety and depression: findings from a population-based prospective cohort study. [PDF]

Front Nutr
Kong Y, Xia W, Wang T, Zhang D.
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Demographic and behavioral correlation of red ginseng consumption in Korea. [PDF]

Integr Med Res
Tian D, Choi K, Kim YU, Lee Y.
europepmc   +1 more source

Practical use and target value of urine sodium-to-potassium ratio in assessment of hypertension risk for Japanese: Consensus Statement by the Japanese Society of Hypertension Working Group on Urine Sodium-to-Potassium Ratio

Hypertension Research
Takashi Hisamatsu, M. Kogure, Y. Tabara, Atsushi Hozawa, A. Sakima, Takuya Tsuchihashi, K. Yoshita, H. Hayabuchi, Koichi Node, Yukari Takemi, T. Ohkubo, Katsuyuki Miura, Katsuyuki Atsushi Yukari Katsuyuki Hitomi Atsushi Mai Miho H Miura Sakima Takemi Ando Hayabuchi Hosawa Kabayama, Katsuyuki Atsushi Yukari Katsuyuki Hitomi Atsushi Mai Miho H Miura Sakima Takemi Ando Hayabuchi Hosawa Kabayama, Katsuyuki Miura, Atsushi Yukari Sakima Takemi, Katsuyuki Hitomi Atsushi Mai Miho Hiroyuki Takuya Yuichiro K Ando Hayabuchi Hosawa Kabayama Kusaka Takase Tsuch, Katsuyuki Ando, Atsushi Hosawa, Mai Kabayama, M. Kusaka, Hiroyuki Takase, Y. Yano, Katsuyuki Takayoshi Yukari Hitomi Takashi Atsushi Atsushi Ya Miura Ohkubo Takemi Hayabuchi Hisamatsu Hozawa Sak, Takayoshi Yukari Ohkubo Takemi, Hitomi Takashi Atsushi Atsushi Yasuharu Takuya Katsushi Hayabuchi Hisamatsu Hozawa Sakima Tabara Tsuchihas, Atsushi Hozawa   +26 more
semanticscholar   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source