Results 271 to 280 of about 1,087,542 (336)

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Association between dietary n-6/n-3 ratio and attention-deficit/hyperactivity disorder among American children and adolescents: findings from the National Health and Nutrition Examination Survey. [PDF]

Lipids Health Dis
Wang L, Wang Y, Li L.
europepmc   +1 more source

Development of Proficiency Testing for Detection of Irradiated Food: Project E01068. Results of First Round PSL Trials, September 2005 [PDF]

, 2007
Alberti, A., Baden, M., Barth, S., Baumann, N., Bergman, M., Brockmann, R., Brown, P., Buranasilp, S., Carmichael, L.A., Chan Sheot Harn, J., Das, R., Dittmar, F., Fisk, S., Gemperle, C., Jung Heon, J., Kay, C., Key, P., Kiryanthan, R., Lardner, C., MacFarlane, S., McKay, K., Niemi, E., Onori, S., Peng, T.S., Pfordt, J., Poulima, I., Pugh, M., Sanderson, D.C.W., Sardone, N., Scott, E.M., Song, I-S., Straub, I., Thompson, M., Todoriki, S., Wiezorek, C., Woo Suk, K.   +35 more
core  

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Associations Between Dietary Habits and Accelerated Aging and the Establishment of an Accelerated Aging Interpretable Risk Prediction Model via Shapley Additive Explanations: Cross-Sectional Study From Two Representative Populations. [PDF]

JMIR Aging
Wu Z, Zhang N, Wang H, Yang Y, Shen H, Zhang Q, Cao Y, Du Y, Ji D.   +8 more
europepmc   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Dose-response relationships of dietary quality with mortality stratified by dietary inflammation and their joint associations among cancer survivors: a population-based cohort study. [PDF]

BMC Public Health
Ma Y, Tian Q, Wu X, Sun Y, Tian J, Xu D, Gong M, Li X, Liu Y, Zhu B.   +9 more
europepmc   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Associations of dietary and blood inflammatory indices with anemia in U.S. adults: Evidence from NHANES 2007 to 2018. [PDF]

Medicine (Baltimore)
Gou X, Chen Z.
europepmc   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source