Results 1 to 10 of about 318,058 (295)

Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults

Frontiers in Pharmacology, 2023
Introduction:Centella asiatica is an herbaceous plant reputed in Eastern medicine to improve memory. Preclinical studies have shown that C. asiatica aqueous extract (CAW) improves neuronal health, reduces oxidative stress, and positively impacts learning
Kirsten M. Wright, Kirsten M. Wright, Melissa Bollen, Melissa Bollen, Jason David, Bridgette Mepham, Armando Alcázar Magaña, Armando Alcázar Magaña, Christine McClure, Claudia S. Maier, Claudia S. Maier, Joseph F. Quinn, Joseph F. Quinn, Joseph F. Quinn, Amala Soumyanath, Amala Soumyanath   +15 more
doaj   +1 more source

The vitamin D paradox in Black Americans: a systems-based approach to investigating clinical practice, research, and public health - expert panel meeting report

BMC Proceedings, 2018
The Office of Dietary Supplements, the National Institute on Minority Health and Health Disparities, the National Institute on Aging, and the National Institute of Diabetes and Digestive and Kidney Diseases, all components of the U.S. National Institutes
LaVerne L. Brown, Barbara Cohen, Derrick Tabor, Giovanna Zappalà, Padma Maruvada, Paul M. Coates   +5 more
doaj   +1 more source

Frequency of CYP2B6 Alleles in Major Iranian Ethnicities, Affecting Response to Efavirenz

Genetics Research, 2022
Introduction. Efavirenz is an antihuman immunodeficiency virus (HIV) drug metabolized by cytochrome P450 2B6 (CYP2B6) enzyme. Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene. Polymorphisms of this gene play a crucial role in
Parham Mardi, Bahareh Tavakoli-Far, Samira Sheibani Nia, Roshanak Jazayeri, Massoud Houshmand   +4 more
doaj   +1 more source

Dietary Supplement Nomenclature

The Primary Care Companion For CNS Disorders, 2016
To the Editor: We very much appreciate Arnold and colleagues’ letter1 and their thoughtful suggestions. The case report by Wong et al2 carefully addressed the concerns regarding nomenclature of supplements as well as the governmental regulations regarding advertising of these increasingly used products.
Michelle K, Wong, Ayeh, Darvishzadeh, Neal A, Maler, Robert G, Bota   +3 more
openaire   +3 more sources

Improving and Comparing Probiotic Plate Count Methods by Analytical Procedure Lifecycle Management

Frontiers in Microbiology, 2021
Probiotics are live microorganisms that confer a health benefit to the host when administered in adequate amounts. This definition links probiotic efficacy to microbial viability. The current gold standard assay for probiotic potency is enumeration using
M. L. Jane Weitzel, M. L. Jane Weitzel, Christina S. Vegge, Marco Pane, Virginia S. Goldman, Binu Koshy, Cisse Hedegaard Porsby, Pierre Burguière, Jean L. Schoeni   +8 more
doaj   +1 more source

Breast cancer prevention with liquiritigenin from licorice through the inhibition of aromatase and protein biosynthesis in high-risk women’s breast tissue

Scientific Reports, 2023
Breast cancer risk continues to increase post menopause. Anti-estrogen therapies are available to prevent postmenopausal breast cancer in high-risk women. However, their adverse effects have reduced acceptability and overall success in cancer prevention.
Atieh Hajirahimkhan, Caitlin Howell, Elizabeth T. Bartom, Huali Dong, Daniel D. Lantvit, Xiaoling Xuei, Shao-Nong Chen, Guido F. Pauli, Judy L. Bolton, Susan E. Clare, Seema A. Khan, Birgit M. Dietz   +11 more
doaj   +1 more source

Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism

Journal of Pharmacological Sciences, 2014
.: The pregnane X receptor (PXR) plays a central role in the regulation of metabolism. Only few PXR antagonists have been described and the mechanism of PXR inhibition is mostly hypothetical or believed to be allosteric.
Tomas Smutny, Petr Pavek
doaj   +1 more source

Allelic and Genotype Frequencies of CYP2B6∗2 (64C > T) and CYP2B6∗3 (777C > A) in Three Dominant Ethnicities of the Iranian Population

Genetics Research, 2023
Background. Cytochrome P450 complex plays a key role in drug metabolism. CYP2B6 has an essential part in Cytochrome P450 complex metabolism. This study aims to determine the allelic distribution of CYP2B6∗2 and CYP2B6∗3 in three main Iranian ethnicities:
Armin Khavandegar, Bahareh Tavakoli-Far, Sarina Ansari, Parisa Veis-Karami, Faezeh Ghasemi, Samira Sheibaninia, Roshanak Jazayeri, Massoud Houshmand   +7 more
doaj   +1 more source

Peripheral Blood DNA Methylation Changes in Response to Centella asiatica Treatment in Aged Mice

Biology
Alterations in epigenetic modifications, like DNA methylation, in peripheral blood could serve as a useful, minimally invasive biomarker of the effects of anti-aging interventions.
Olivia Monestime, Brett A. Davis, Cora Layman, Kandace J. Wheeler, Wyatt Hack, Jonathan A. Zweig, Amala Soumyanath, Lucia Carbone, Nora E. Gray   +8 more
doaj   +1 more source

Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration

Frontiers in Aging
Background: A water extract (CAW) of the Ayurvedic plant Centella asiatica administered in drinking water has been shown to improve cognitive deficits in mouse models of aging and neurodegenerative diseases.
Nora E. Gray, Nora E. Gray, Wyatt Hack, Wyatt Hack, Mikah S. Brandes, Mikah S. Brandes, Jonathan A. Zweig, Jonathan A. Zweig, Liping Yang, Liping Yang, Luke Marney, Luke Marney, Jaewoo Choi, Jaewoo Choi, Armando Alcazar Magana, Armando Alcazar Magana, Natasha Cerruti, Natasha Cerruti, Janis McFerrin, Janis McFerrin, Seiji Koike, Seiji Koike, Thuan Nguyen, Thuan Nguyen, Jacob Raber, Jacob Raber, Joseph F. Quinn, Joseph F. Quinn, Joseph F. Quinn, Claudia S. Maier, Claudia S. Maier, Claudia S. Maier, Amala Soumyanath, Amala Soumyanath   +33 more
doaj   +1 more source