Results 61 to 70 of about 20,408 (237)

Assessing the presence of Wuchereria bancrofti in vector and human populations from urban communities in Conakry, Guinea [PDF]

, 2015
The Global Programme to Eliminate Lymphatic Filariasis was launched in 2000 with the goal of interrupting transmission of lymphatic filariasis (LF) through multiple rounds of mass drug administration (MDA).
Boakye, Daniel A., Bockarie, Moses J., Dadzie, Samuel K., de Souza, Dziedzom K., Diakité, Lamia, Goepogui, Andre, King, Sandra A., Kouassi, Bernard L., Koudou, Benjamin G., Mamadou, Baldé S., Narh, Charles A., Utzinger, Jürg   +11 more
core   +3 more sources

Investigation of a fully mechanistic physiologically based pharmacokinetics model of absorption to support predictions of milk concentrations in breastfeeding women and the exposure of infants: A case study for albendazole

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 11, Page 1990-2001, November 2024.
Abstract Due to limited non‐clinical and clinical data, European guidance recommends to discontinue breastfeeding when taking albendazole. The aim of this study was to consider the use of PBPK modeling to support the expected exposure in breastfed infants. A fully mechanistic PBPK approach was used to provide quantitative predictions of albendazole and
Susan Cole, Maria Malamatari, Andrew Butler, Mahnoor Arshad, Essam Kerwash   +4 more
wiley   +1 more source

Calcification of the breasts due to loiasis

IDCases, 2016
A 53-year-old HIV-positive female from Cameroon was diagnosed with loiasis in 2013 due to symptoms of polyarthritis and laboratory confirmed eosinophilia.
Eva Lemmenmeier, Nicole Keller, Natalie Chuck   +2 more
doaj   +1 more source

Pharmacokinetics of Diethylcarbamazine: Prediction by Concentration in Saliva.

Biological and Pharmaceutical Bulletin, 2000
The concentration of diethylcarbamazine in saliva was used to determine pharmacokinetic parameters, in comparison to plasma and urine concentrations. Six healthy adult male volunteers were administered 150 mg diethylcarbamazine with 400 ml of water.
C. N. Orish, Orish Ebere Orisakwe, Sabinus Ofoefule, Onyenmechi Johnson Afonne, E. Obi, Ndidi Ilondu, KC Chilaka   +6 more
openaire   +4 more sources

Systematic review of the evidence for treatment and management of common skin conditions in resource‐limited settings: An update

Tropical Medicine &International Health, Volume 29, Issue 11, Page 923-950, November 2024.
Abstract Introduction The skin is the largest and most visible organ of the human body. As such, skin infections can have a significant impact on overall health, social wellbeing and self‐image. In 2019, we published a systematic review of the treatment, prevention and public health control of skin infections including impetigo, scabies, crusted ...
Ingrid Amgarth‐Duff, Hannah Thomas, Bernadette M. Ricciardo, Lorraine Anderson, Mike Stephens, Bart J. Currie, Andrew C. Steer, Steven Y. C. Tong, Kristy Crooks, Allison Hempenstall, Artiene Tatian, Rachel Foster, George Kavalam, Tharushi Pallegedara, Kennedy Walls, Asha Bowen   +15 more
wiley   +1 more source

Retroperitoneal Cyst: An Uncommon Presentation of Filariasis

Case Reports in Surgery, 2015
Primary retroperitoneal parasitic cysts are rare. Here we report about a middle aged male patient from rural north India with a recent onset of central abdominal retroperitoneal lump, pain, and fever.
Senthil Ganesan, Saurabh Galodha, Rajan Saxena   +2 more
doaj   +1 more source

Reduction in acute filariasis morbidity during a mass drug administration trial to eliminate lymphatic filariasis in Papua New Guinea. [PDF]

, 2011
Background Acute painful swelling of the extremities and scrotum are debilitating clinical manifestations of Wuchereria bancrofti infection. The ongoing global program to eliminate filariasis using mass drug administration is expected to decrease this
A Joseph, AS Kerketta, B Genton, Benson Kiniboro, BV Babu, D Kyelem, Daniel J. Tisch, DB Gasarasi, DG Addiss, DG Addiss, DJ Tisch, EA Ottesen, EA Ottesen, EA Ottesen, EA Ottesen, FE Ciferri, G Dreyer, G Dreyer, G Dreyer, Helton da Costa Santiago, Henry Dagoro, J Horton, James W. Kazura, JO Gyapong, JO Gyapong, KM Pfarr, M Bockarie, Michael P. Alpers, MJ Bockarie, MJ Bockarie, MJ Taylor, Moses J. Bockarie, ND Alexander, ND Alexander, Neal D. E. Alexander, Peter M. Siba, PJ Lammie, PK Das, RK Shenoy, RM Ramzy, RS Wijesinghe, S Bennuru, SF Wilson, SR Narahari, T McPherson, TB Nutman, TK Suma   +46 more
core   +4 more sources

A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose Trial of AWZ1066S, an Anti‐Wolbachia Candidate Macrofilaricide

Clinical Pharmacology in Drug Development, Volume 13, Issue 9, Page 1071-1081, September 2024.
Abstract AWZ1066S has been developed as a potential treatment for the neglected tropical diseases lymphatic filariasis and onchocerciasis. AWZ1066S targets the Wolbachia bacterial endosymbiont present in the causative nematode parasites. This phase 1, first‐in‐human study aimed to assess the safety and pharmacokinetics of AWZ1066S in healthy human ...
Graham Devereux, Marcin Bula, Karen Tripp, Richard Fitzgerald, Nicola Eraut, Muhammad Salman Alam, Tomoyuki Moriyama, Raku Shinkyo, Lauren Walker, Duolao Wang, Fabian Gusovsky, Jeannette van der Velde, Joseph D. Turner, Weiqian David Hong, Paul M. O'Neill, Mark J. Taylor, Stephen A. Ward   +16 more
wiley   +1 more source

Incidental Detection Microfilaria in Subcutaneous Breast Nodule of Lactating Female Fnac: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2014
Filariasis is a major public health problem which is faced in tropical countries like India. Its diagnosis is made by using peripheral blood smears. However, microfilaria has been detected incidentally during FNACs of various lesions, which were done in
Ajay KR. Singh, Prashant Gupta, Soma Yadav, H.S. Pahawa   +3 more
doaj   +1 more source

Emerging connectivity of programmed cell death pathways and pulmonary vascular remodelling during pulmonary hypertension

Journal of Cellular and Molecular Medicine, Volume 28, Issue 16, August 2024.
Abstract Pulmonary hypertension (PH) is a chronic progressive vascular disease characterized by abnormal pulmonary vascular resistance and pulmonary artery pressure. The major structural alteration during PH is pulmonary vascular remodelling, which is mainly caused by the imbalance between proliferation and apoptosis of pulmonary vascular cells ...
Meng‐nan Yuan, Ting Liu, An‐qi Cai, Zibo Zhan, Yi‐li Cheng, Qi‐yue Wang, Yu‐xuan Xia, Nong‐er Shen, Ping Huang, Xiao‐zhou Zou   +9 more
wiley   +1 more source