Results 51 to 60 of about 336,140 (171)

A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose Trial of AWZ1066S, an Anti‐Wolbachia Candidate Macrofilaricide

Clinical Pharmacology in Drug Development, Volume 13, Issue 9, Page 1071-1081, September 2024.
Abstract AWZ1066S has been developed as a potential treatment for the neglected tropical diseases lymphatic filariasis and onchocerciasis. AWZ1066S targets the Wolbachia bacterial endosymbiont present in the causative nematode parasites. This phase 1, first‐in‐human study aimed to assess the safety and pharmacokinetics of AWZ1066S in healthy human ...
Graham Devereux, Marcin Bula, Karen Tripp, Richard Fitzgerald, Nicola Eraut, Muhammad Salman Alam, Tomoyuki Moriyama, Raku Shinkyo, Lauren Walker, Duolao Wang, Fabian Gusovsky, Jeannette van der Velde, Joseph D. Turner, Weiqian David Hong, Paul M. O'Neill, Mark J. Taylor, Stephen A. Ward   +16 more
wiley   +1 more source

A comparison of the efficacy of single doses of albendazole, ivermectin, and diethylcarbamazine alone or in combinations against Ascaris and Trichuris spp.

Bulletin of the World Health Organization, 2003
OBJECTIVE: To determine the efficacy of single doses of albendazole, ivermectin and diethylcarbamazine, and of the combinations albendazole + ivermectin and albendazole + diethylcarbamazine against common intestinal helminthiases caused by Ascaris and ...
Belizario V.Y., Amarillo M.E., Leon W.U. de, Reyes A.E. de los, Bugayong M.G., Macatangay B.J.C.   +5 more
doaj  

Emerging connectivity of programmed cell death pathways and pulmonary vascular remodelling during pulmonary hypertension

Journal of Cellular and Molecular Medicine, Volume 28, Issue 16, August 2024.
Abstract Pulmonary hypertension (PH) is a chronic progressive vascular disease characterized by abnormal pulmonary vascular resistance and pulmonary artery pressure. The major structural alteration during PH is pulmonary vascular remodelling, which is mainly caused by the imbalance between proliferation and apoptosis of pulmonary vascular cells ...
Meng‐nan Yuan, Ting Liu, An‐qi Cai, Zibo Zhan, Yi‐li Cheng, Qi‐yue Wang, Yu‐xuan Xia, Nong‐er Shen, Ping Huang, Xiao‐zhou Zou   +9 more
wiley   +1 more source

What is the role of microbial biotechnology and genetic engineering in medicine?

MicrobiologyOpen, Volume 13, Issue 2, April 2024.
Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley   +1 more source

Poly (Diethylcarbamazine) electropolymerized carbon paste electrode: A simple and reliable sensor for vanillin quantification in food products

Next Materials
This study introduces a new poly (diethylcarbamazine citrate)-modified carbon paste electrode (poly-DEC/MCPE) electrochemical sensor for the rapid and sensitive detection of vanillin (VLN), an aromatic phenolic compound used in food and pharmaceuticals ...
Swastika N. Das, Kailash S. Chadchan, Shabanazami Attar, Amit B. Teradale, Ahmed Aliyu, Omolola Esther Fayemi   +5 more
doaj   +1 more source

Isolated perinephric abscess as the initial manifestation of filariasis—an unusual presentation

Clinical Case Reports, Volume 12, Issue 3, March 2024.
Graphical Abstract Key Clinical Message Filariasis may present as an isolated perinephric abscess. Hence, a high index of suspicion should be maintained in endemic settings. Abstract In cases with unexplained fever, eosinophilia and perinephric collection, it is necessary to do detailed infectious disease work up. High index of suspicion is required to
Govind Sharma, Rajat Sachdeva, Shweta Aggarwal, Amogh Verma, Ayush Anand, Ajeet Singh, Prakasini Satapathy   +6 more
wiley   +1 more source

Diagnosis of O. volvulus infection via skin exposure to diethylcarbamazine: clinical evaluation of a transdermal delivery technology-based patch

Parasites & Vectors, 2015
Background Elimination of onchocerciasis in Africa is now regarded as an achievable goal in many areas. This makes monitoring changes in infection prevalence a key component of control programmes. Monitoring is currently based on determining the presence
K. Awadzi, Nicholas O. Opoku, Simon K. Attah, Janis K. Lazdins-Helds, Annette C. Kuesel   +4 more
doaj   +1 more source

Role of PASCAL and optical coherence tomography angiograpgy in the treatment of diffuse unilateral subacute neuroretinitis caused by large live motile worm

Indian Journal of Ophthalmology, 2019
A 46-year-old male presented with best corrected visual acuity (BCVA) of 20/125 in his right eye. Fundus showed disc edema, multiple yellow outer retinal crops, macular edema and a live motile worm in the subretinal space. Diagnosis of diffuse unilateral
Navya Cherukuri, Bhavik Panchal, Hrishikesh Kaza, Shreyansh Doshi, Avinash Pathengay   +4 more
doaj   +1 more source

A large filarial hydrocele in Kenya: a case report

Frontiers in Tropical Diseases
Morbidity Management and Disability Prevention (MMDP) remains a key aspect of the Global project for the Elimination of Lymphatic Filariasis (GPELF) a program launched by WHO in the year 2000.
Charles Waihenya, Sheila Githui, Edgard Schouame   +2 more
doaj   +1 more source

Vector control complements mass drug administration against bancroftian filariasis in Tirukoilur, India

Bulletin of the World Health Organization, 2007
OBJECTIVE: To determine the role of vector control in further decreasing the transmission of bancroftian filariasis achieved by mass drug administration and the long-term impact on filariometric indices.
IP Sunish, R Rajendran, TR Mani, A Munirathinam, AP Dash, BK Tyagi   +5 more
doaj