Results 51 to 60 of about 334,424 (174)

An open label, block randomized, community study of the safety and efficacy of co-administered ivermectin, diethylcarbamazine plus albendazole vs. diethylcarbamazine plus albendazole for lymphatic filariasis in India.

PLoS Neglected Tropical Diseases, 2021
BackgroundBetter drug regimens for mass drug administration (MDA) could accelerate the Global Programme to Eliminate Lymphatic Filariasis (LF).
Purushothaman Jambulingam, Vijesh Sreedhar Kuttiatt, Kaliannagounder Krishnamoorthy, Swaminathan Subramanian, Adinarayanan Srividya, Hari Kishan K Raju, Manju Rahi, Roopali K Somani, Mallanna K Suryaprakash, Gangeshwar P Dwivedi, Gary J Weil   +10 more
doaj   +1 more source

A State‐of‐the‐Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines

Advanced NanoBiomed Research, Volume 5, Issue 3, March 2025.
Nanomaterial‐integrated microneedles revolutionize transdermal delivery, enabling targeted and controlled administration of therapeutics and vaccines. This review explores advancements in design, manufacturing, and applications, emphasizing enhanced drug stability, bioavailability, and patient adherence. Key preclinical and clinical findings as well as
Bwalya Angel Witika, Aaron Hutton, Pedzisai A. Makoni, Ryan F. Donnelly   +3 more
wiley   +1 more source

Protothecosis in Dogs: A Narrative Review

Journal of Veterinary Internal Medicine, Volume 39, Issue 2, March/April 2025.
ABSTRACT Protothecosis is a rare and unusual disease that affects both humans and animals, including dogs. The causative agents are unicellular, achlorophyllous, “yeast‐like” microalgae of the genus Prototheca (Trebouxiophyceae, Chlorophyta). Although usually saprophytic, Prototheca may, under conditions of immunologic compromise, become pathogenic and
Tomasz Jagielski, Angelika Proskurnicka, Mateusz Iskra, Sylwia Wronka, Zofia Bakuła, Patrizia Danesi, Marconi Rodrigues de Farias, Fábio Vinícius Ramos Portilho, Márcio Garcia Ribeiro, Uwe Rösler, Rui Kano, Richard Malik   +11 more
wiley   +1 more source

Neglected Tropical Diseases and Female Infertility: Possible Pathophysiological Mechanisms

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Battling female infertility has posed a global challenge, where neglected tropical diseases (NTDs) are nonetheless a notable contributing factor. NTDs affect a variety of diseases, often of a chronic nature, which are often cited as some of the most lethal diseases operating against the most economically disadvantaged populations across the globe.
Moses Agbomhere Hamed, Olabanji Ahmed Surakat, Victor Olukayode Ekundina, Kabirat Bolajoko Jimoh, Adetomiwa Ezekiel Adeogun, Nafisat Omolola Akanji, Oluwafemi Joshua Babalola, Patrick Chukwunonso Eya, Rajib Chowdhury   +8 more
wiley   +1 more source

Effects of rifampicin and ketoconazole on the pharmacokinetics of a single oral dose of diethylcarbamazine in healthy volunteers

Journal of Health Science and Medical Research (JHSMR), 2006
Diethylcarbamazine (DEC) is the first-line drug for the control and treatment of lymphatic filariasis caused by the Wuchereria bancrofti and Brugia malayi parasite. DEC is rapidly and extensively metabolised in the liver.
W Ridtitid, M Wongnawa, W Mahatthanatrakul, A Pattanawongsa, N Bumrungwong, M Sunbhanich   +5 more
doaj  

Diethylcarbamazine (dec) protects against acute hepatotoxicity induced by carbon tetrachloride (ccl4) in mice by modulating pro-inflammatory markers through autophagy activation [PDF]

Brazilian Journal of Pharmaceutical Sciences
The current study examined the effects of Diethylcarbamazine (DEC) on CCl4-induced liver toxicity and the autophagic process in mice. A dose of 50mg/kg of DEC was intragastrically administered for 12 days before the CCl4 (10%,v/v in olive oil, 2ml/kg ...
Sura Wanessa Santos Rocha, Maria Eduarda de Rocha França, Wilma Helena Oliveira, Deniele Bezerra Lós, Débora Dantas Nucci Cerqueira, Amanda Mota Vieira, Bruno Melo Carvalho, Christina Alves Peixoto   +7 more
doaj   +1 more source

Genetic, Immunological, and Public Health Perspectives on Podoconiosis

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Podoconiosis is a neglected tropical disease (NTD) that primarily affects poor communities in tropical regions, particularly in sub‐Saharan African countries. The disease results from prolonged contact with red clay soils, leading to chronic lymphedema of the lower limbs.
Tsegahun Asfaw Abebe, Abiola Isawumi, Lipi Buch   +2 more
wiley   +1 more source

Investigation of a fully mechanistic physiologically based pharmacokinetics model of absorption to support predictions of milk concentrations in breastfeeding women and the exposure of infants: A case study for albendazole

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 11, Page 1990-2001, November 2024.
Abstract Due to limited non‐clinical and clinical data, European guidance recommends to discontinue breastfeeding when taking albendazole. The aim of this study was to consider the use of PBPK modeling to support the expected exposure in breastfed infants. A fully mechanistic PBPK approach was used to provide quantitative predictions of albendazole and
Susan Cole, Maria Malamatari, Andrew Butler, Mahnoor Arshad, Essam Kerwash   +4 more
wiley   +1 more source

Systematic review of the evidence for treatment and management of common skin conditions in resource‐limited settings: An update

Tropical Medicine &International Health, Volume 29, Issue 11, Page 923-950, November 2024.
Abstract Introduction The skin is the largest and most visible organ of the human body. As such, skin infections can have a significant impact on overall health, social wellbeing and self‐image. In 2019, we published a systematic review of the treatment, prevention and public health control of skin infections including impetigo, scabies, crusted ...
Ingrid Amgarth‐Duff, Hannah Thomas, Bernadette M. Ricciardo, Lorraine Anderson, Mike Stephens, Bart J. Currie, Andrew C. Steer, Steven Y. C. Tong, Kristy Crooks, Allison Hempenstall, Artiene Tatian, Rachel Foster, George Kavalam, Tharushi Pallegedara, Kennedy Walls, Asha Bowen   +15 more
wiley   +1 more source

A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose Trial of AWZ1066S, an Anti‐Wolbachia Candidate Macrofilaricide

Clinical Pharmacology in Drug Development, Volume 13, Issue 9, Page 1071-1081, September 2024.
Abstract AWZ1066S has been developed as a potential treatment for the neglected tropical diseases lymphatic filariasis and onchocerciasis. AWZ1066S targets the Wolbachia bacterial endosymbiont present in the causative nematode parasites. This phase 1, first‐in‐human study aimed to assess the safety and pharmacokinetics of AWZ1066S in healthy human ...
Graham Devereux, Marcin Bula, Karen Tripp, Richard Fitzgerald, Nicola Eraut, Muhammad Salman Alam, Tomoyuki Moriyama, Raku Shinkyo, Lauren Walker, Duolao Wang, Fabian Gusovsky, Jeannette van der Velde, Joseph D. Turner, Weiqian David Hong, Paul M. O'Neill, Mark J. Taylor, Stephen A. Ward   +16 more
wiley   +1 more source