Results 1 to 10 of about 40,552 (199)

Prenatal Exposure to Bisphenol A and/or Diethylhexyl Phthalate Impacts Brain Monoamine Levels in Rat Offspring [PDF]

Journal of Xenobiotics
This study examines the sex-specific effects of gestational exposure (days 6–21) to endocrine-disrupting chemicals such as bisphenol A (BPA), diethylhexyl phthalate (DEHP), or their combination on brain monoamine levels that play an important role in ...
Amrita Kaimal, Jessica M. Hooversmith, Maryam H. Al Mansi, Philip V. Holmes, Puliyur S. MohanKumar, Sheba M. J. MohanKumar   +5 more
doaj   +3 more sources

Diethylhexyl phthalate exposure promotes mitophagy through Drp1-mediated mitochondrial fission in neural crest cells of chick embryos [PDF]

Poultry Science
Di(2-ethylhexyl) phthalate (DEHP) has been used commonly in industrial production and has endocrine disrupting ability. DEHP has potential adverse effects on the development of fetal programming, but the toxic effects and mechanism study in neural crest ...
Yi Li, Fan Yang, Chenghong Xing, Penghui Liu, Yike Zhang, Caiying Zhang, Jirong Chen, Huabin Cao, Xueyan Dai   +8 more
doaj   +3 more sources

Association Between Diethylhexyl Phthalate Exposure and Thyroid Function: A Meta-Analysis. [PDF]

Thyroid, 2019
Diethylhexyl phthalate (DEHP) is widely used in industrial products, particularly as plasticizers and softeners. Because it is used extensively, DEHP has been detected in humans worldwide. Although epidemiological studies suggest that DEHP can disrupt the function of the hypothalamic-pituitary-thyroid (HPT) axis, evidence on the association between ...
Kim MJ, Moon S, Oh BC, Jung D, Choi K, Park YJ.   +5 more
europepmc   +5 more sources

Environmental Chemical Diethylhexyl Phthalate Alters Intestinal Microbiota Community Structure and Metabolite Profile in Mice [PDF]

mSystems, 2019
Exposure to environmental chemicals during windows of development is a potentially contributing factor in gut microbiota dysbiosis and linked to chronic diseases and developmental disorders.
Ming Lei, Rani Menon, Sara Manteiga, Nicholas Alden, Carrie Hunt, Robert C. Alaniz, Kyongbum Lee, Arul Jayaraman   +7 more
doaj   +5 more sources

Intrauterine exposure to diethylhexyl phthalate disrupts gap junctions in the fetal rat testis [PDF]

Current Research in Toxicology, 2020
Fetal exposure to certain phthalate esters can disrupt testis development in rodents and lead to male reproductive disorders, but with a causal link less certain in humans.
Mariana Di Lorenzo, Sofia Boeg Winge, Terje Svingen, Maria De Falco, Julie Boberg   +4 more
doaj   +6 more sources

Prenatal exposure to bisphenol A and/or diethylhexyl phthalate alters stress responses in rat offspring in a sex- and dose-dependent manner. [PDF]

Front Toxicol, 2023
Background: Prenatal exposures to endocrine disrupting chemicals (EDCs) are correlated with adverse behavioral outcomes, but the effects of combinations of these chemicals are unclear.
Kaimal A, Hooversmith JM, Cherry AD, Garrity JT, Al Mansi MH, Martin NM, Buechter H, Holmes PV, MohanKumar PS, MohanKumar SMJ.   +9 more
europepmc   +2 more sources

Role of Hepatocyte- and Macrophage-Specific PPARγ in Hepatotoxicity Induced by Diethylhexyl Phthalate in Mice. [PDF]

Environ Health Perspect, 2022
Background: Phthalates may disturb metabolic homeostasis in the liver by interfering with the peroxisome proliferator-activated receptors (PPARs). However, the role of hepatic macrophages in the lipid metabolic dysregulation induced by diethylhexyl ...
Xu M, Li Y, Wang X, Zhang Q, Wang L, Zhang X, Cui W, Han X, Ma N, Li H, Fang H, Tang S, Li J, Liu Z, Yang H, Jia X.   +15 more
europepmc   +2 more sources

Prenatal bisphenol A and/or diethylhexyl phthalate exposure followed by adult estradiol treatment affects behavior and brain monoamines in female rat offspring. [PDF]

Front Endocrinol (Lausanne)
Significance Women are at increased risk for mood disorders, which may be partly attributed to exposure to endocrine-disrupting chemicals (EDCs) during sensitive periods such as pregnancy.
Kaimal A, Hooversmith JM, Al Mansi MH, Cherry AD, Garrity JT, Holmes PV, MohanKumar PS, MohanKumar SMJ.   +7 more
europepmc   +2 more sources

Association between Diethylhexyl Phthalate Exposure with Folliculogenesis and Ovarian Steroidogenesis: A Systematic Review and Meta-Analysis

Clinical and Experimental Obstetrics & Gynecology, 2023
Background: Environmental endocrine disruptor-diethylhexyl phthalate (DEHP) or its active metabolites-mono(2-ethylhexyl) phthalate (MEHP) has the greatest endocrine disrupting potency.
Weihuan Hu, Yan Wu, Yuhang Zhu, Fangfang Wang, Fan Qu   +4 more
doaj   +2 more sources

Perinatal Exposure to Lead or Diethylhexyl Phthalate in Mice: Sex-Specific Effects on Cardiac DNA Methylation and Gene Expression across Time. [PDF]

Environ Health Perspect
Background: Global and site-specific changes in DNA methylation and gene expression are associated with cardiovascular development, aging, and disease, but how the transcriptome and epigenome of the heart change across the life course in males vs ...
Wang K, Li M, Sartor MA, Colacino JA, Dolinoy DC, Svoboda LK.   +5 more
europepmc   +2 more sources