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Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Differences in Income Growth Between People With Multiple Sclerosis and Controls: A Norwegian Cohort Study. [PDF]

Eur J Neurol
Høgset A, Simonsen CS, Flemmen HØ, Brunborg C, Broch L, Berg-Hansen P, Celius EG.   +6 more
europepmc   +1 more source

Spatiotemporal localization of sex difference in plantar pressure distribution during self paced walking in healthy Japanese adults. [PDF]

PLoS One
Doi H, Furuta N, Yoon H, Funato K.
europepmc   +1 more source

Simulation Study on Dielectric Constant Sensing by Interference of Spoof Surface Plasmon Polaritons. [PDF]

Micromachines (Basel)
Zeng T, Bi C, Zhou J, Gong S.
europepmc   +1 more source

The Contribution of Chemistry to the Detection and Enumeration of Legionella pneumophila in Environmental Water Samples: Experience With the MICA Method. [PDF]

Microbiologyopen
Ditommaso S, Garlasco J, Streva C, Memoli G, Zotti CM, Bert F, Giacomuzzi M.   +6 more
europepmc   +1 more source

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Generalized Difference-in-Differences

Epidemiology, 2022
Difference-in-differences (DID) analyses are used in a variety of research areas as a strategy for estimating the causal effect of a policy, program, intervention, or environmental hazard (hereafter, treatment). The approach offers a strategy for estimating the causal effect of a treatment using observational (i.e., nonrandomized) data in which ...
David B. Richardson, Ting Ye, Eric J. Tchetgen Tchetgen   +2 more
openaire   +2 more sources